I think you have gotten some good advice but just wanted to add one thing. X breeds are not a guarantee against inherited problems. You could just as well get inherited problems from the mums breed and the dads breed. Although I would always want to encourage people to rescue a dog from a shelter, if you are after something specific like a dane then you may be better off going with a pure bred from a breeder that screens their breeding dogs for potential problems (e.g. like hip scoring for breeds that tend to hip dysplasia). Just something to think about Beautiful dogs though!