I had an an amino at 21 weeks with DS2, but we knew something was wrong. It wasn't T21. In fact, he was chromosomally normal. Our risk with him was 1:6000 for T21. We'd decided we'd think about it if the risk was 1:300 or worse. I'm 38 now, so the risk level jumps up.

Given our history of loss, I'm reluctant to consider amnio unless there are other risk factors identified. It's a tough decision. What was the risk before the blood test? An OB we had for scans told me the bloodwork is only 10% of the final result.

Perhaps you need to discuss with a genetic counsellor before making the decison.

Btw, the amnio was painful but quick. For us, the grief was a compounding factor. I just breathed through it.