If a Rh- woman has a Rh+ partner, it's very likely that their baby will be Rh+. This means that if her blood comes into contact with her baby's, she'll develop antibodies to it. This is unlikely to happen during a first pregnancy, but can happen when the baby is being born, when some of its blood may get into her circulation. It can also happen if she has a miscarriage or a termination or, occasionally, after an amniocentesis or CVS test. If it does happen, the woman will produce antibodies to the Rh+ blood. They won't affect her first baby at all, but they'll stay in her blood and if she becomes pregnant again, problems can arise.
If a Rh- woman who has antibodies in her blood is pregnant with a Rh+ baby, it's possible for her antibodies to pass through to the baby and damage or even destroy the baby's red blood cells. This can lead to the baby becoming anaemic or developing jaundice, or occasionally to more serious complications
Fortunately, Rhesus factor problems are almost entirely preventable. Women who are Rh- are routinely given an injection of a substance called Anti-D shortly after the baby is born (or after a miscarriage or termination). This destroys any Rh+ cells that may have got into the bloodstream so that they won't produce any more antibodies.
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