I have had heaps of skin tags in my time. If I can I tie them off like someone else mentioned. If it pinches too much I just tie it not so tightly and as the area loses blood supply it is less sensitive and I can tie it a bit tighter. Often though they don't have too much feeling and I can tie them pretty tight the first time. Eventually then they just fall off and I don't even usually notice. I have one under my eye at the moment but firstly it isn't big enough to tie and secondly I would do it there as it is so close to my eye and it takes a few days to work so would look like a freak. A really sensitive area I would probably check it is ok to do first. HTH.