Yes, that's right Michelle both CD56 are positive it's just the CD16 that has a differing +/-.
I believe, that what occurs is that the opposing NKcells attack the placenta. I also believe that how early the miscarriage occurs is often due to the large number of NK cells.

It is thought that by about 20 weeks of pregnancy there are almost no killer cells left so this is not an issue. It is thought that NK cells most often cause early losses (before 12 weeks) though it's possible that they could contribute to the later losses if the level of circulating NK cells wasn't quite as high. This would make sense to me as the function of the placenta is really called into action at around 13 weeks...

This is why for women who have NK cells prednisone and asprin is taken preconceptually. (in fact for many autoimmune disorders of pregnancy the treatment is preconceptual) It is believed with women with an NK cell issue the hostility begins from the word dot. So as soon as conception occurs the reaction commences.

As you know the preconceptual asprin aids in implantation and also helps the platelets to be less "sticky" so this is where the asprin plays the early part.

Clexane is often commenced at ovulation but I have seen studies that don't support this and prefer to start from a positive preg test. I believe Dr S begins clexane when he can see a sac on u/s at around 4.6 weeks (to rule out ectopic pregnancy and the issues if clexane is on board).

My previous doctor argued with me (how dare him!) that if prednisone worked for everyone everyone would need it. However, it has to be remembered that clexane also has a mild autoimmune inhibiting action and this combined with asprin can be enough for many women.
I personally don't want to risk it what if I fall in the 5 percent of women that need the prednisone? I will commence my prednisone on Tuesday next week just prior to expected ovulation and will take it until I confirm pregnancy or a period. Of course if I do conceive I will stay on it! I believe that the prednisone doseage begins to be decreased at around 20 weeks until you are weaned. It is felt and it seems that it is usually right that the prednisone has little benefit after 20 weeks. However, I would need to look into this more to feel comfortable. I am only doing this as you know as a precaution. I don't know if I have NK cells as I haven't had the endometrial biopsy done (this can only be done by Dr S in Sydney).

Most women test negative for serum NK cells even if they have uterine nk cells on biopsy. Dream I believe tested positive with serum so her NK cells are quite prolific I think (help me out Dream what were they do you recall???)

In my case I believe I have something that is mimicing antiphospholipid syndrome. I have a history of thrombocytopenia in pregnancy, gestational diabetes, my thyroid is on the lower end of normal my ana is borderline. Everything just scrapes in. I believe that in my personal situation that I have had some type of funny autoimmune thing happening for a long time.
When I was around 14 I developed severe swelling to all my joints which made walking almost impossible and extreme fatigue. I tested neg to all suspected things like RRV, Dengue etc etc. In about 6 weeks it cleared but since then every few months I develop a ring like rash on my torso that isn't itchy but is raised. (reminds me vaguely of the butterfly rash of SLE [lupus])

I have thought this for a very long time but I didn't follow through I just listened to my doctor and not my self.

So, this time I will have all guns on board and I feel pretty confident that I will get a take home baby or two!

Please know that I am not suggesting that every woman needs prednisone/asprin/clexane.