What Rouge said.

I think for me I would have to decide whether I could detach from them emotionally or not in terms of just becoming task focused at work and enjoying the enjoyable bits. I would stop making so many concessions in my life for them. I would bend over backwards for close friends or family but not for a work situation. If you can detach and get to a place of task focus, then keep going. Otherwise I would look for alternative jobs where I could do the same type of work or even look into setting up my own business - sounds like you have great ideas and good relationships with clients!