As chocoholic said, is it something that is likely to be offered again? If no (or not for a long time) will you regret not taking the opportunity?
To be honest, I think that from the vibe of your post you really want to do the job, and in that case, do it. If you are happy with what you are doing then you will probably find that will then reflect on how happy you are at home (well at least that is the case for me).
I would want to only work 4 days a week, with one of those being from home. This is the current arrangement that I have and that's one thing that is not negotiable to me.
I've done a list of things that I'd expect from my new employer and I'll be having a proper chat with them later today so I'll get a better idea of what's on offer.
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