There has been studies on cats. Basically from what I can recall problems did not appear in the first generation, but in the ones that came after and they were so bad, that the study basically had to stop/was stopped due to the cats being unable to breed/survive (**disclaimer I am doing this from memory, so I could be wrong, will google now to see if I can find a reference to the study). I recall hearing about this, but it was in an article/discussion about why we "suddenly" seem to have an issue with gluten.
ETA: Pottenger's s cats - Study on how inherited degenerative disease is caused by improper nutrition that weakens the genetic code you pass to your children. *Warning - don't look up if you are a bit sensitive*






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