I think that just as long as the head can grow that the shape isn't a health issue. Lots of people have funny shaped heads but usually they have hair that covers it and as they mature babies heads seem to take on more normal shapes.
If you do decide to say something maybe try to sandwich it between positive comments about how cute he is.
DD had plagiocephaly, and it was deemed to be 'moderate: requiring attention' because it was starting to involve her ears and face (one ear was more forward than the other and her forehead was bulging one on side because the skull was becoming so out of shape from the flat spot). She also had torticolis, a neck muscle issue, so a lot of physio was required but because we started treatment at around 4-5 months of age she didn't need a helmet.
On one hand, you don't want to offend or cause her to worry, but untreated plagiocephaly can become an issue (mostly cosmetic) if it is moderate to severe - can impact on the position of the ears, eyes and also jaw alignment which is the major cause of issues later on. If you are still in contact with your MCHN, can you get some info and then casually pass it on to your friend next time you see her?
I would say something. My DD2 had a flat spot on one side and with some attention I corrected it easily enough. My friends little boy had it alot worse, to the point of head moulds constantly been made and a lot of physio.
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