Losec should be taken half an hour prior to a feed so it has time to kick in. I found the best way to do it is to put the 1/2 tablet into the syringe & then suck the water up into it, that way you make sure you get the entire dose in the syringe. And yep definitely don't crush the balls, they need to be intact to work properly. I wouldn't make it up too long prior to giving it to him as the balls will turn brown & I'm not so sure that that's a good thing! Might be ok, but I wouldn't do it personally.