anyos, I've always been a total needle-phobe but I've managed to do all my puregon injections for 3 IUI and 3 IVF cycles without incident (something like 60 shots all up). It took a while to get used to the idea psychologically, but the pens make the injections so easy physically. I've never noticed any side effects from the puregon (except maybe some mood swings?), but the synarel has always been a shocker for me in terms of side effects.