Update - My sister ending up testing positive for MTHFR, she then transferred to another fertility specialist as she wasn't happy with the protocol her old specialist was following. Her second cycle at the new place she commenced antibiotics, steroids and low dose aspirin at her request and with the support of her new Dr and had 2 FET and is now 8 weeks pregnant with one bubba. I am so over the moon for her, can't explain how happy I am so I can only imagine how she and her DH feel!