I too have been speaking with FS about the issue of failing to implant. This seems to be my major issue, I stim well, good number of follies, good number of eggs, fert is fine, growth is ok (better when I haven't overstimmed), good quality blasties, but no luck with a BFP.
He has recommended the Colorado Protocol for next stim cycle, aparently designed to alter you immune system and improve the endo lining to aid in implantation. I had also asked for more tests and he has given me:
Karoytype
Antithrombin III
Protein S & C
Factor 5 Lieden
Prothrombin gene
Anti beta 2 glycoprotein 1 (IgG & IgM)
ACA, ANA (DNA & ENA if indic) DSDNA, LAC
Homocystine
TSH
Prolactin
Some you guys have mentioned, some not, and I have no idea at all what they all mean.
Will let you know my results once they are in and will stay tuned to see how you all go. Hugs xx
Got my results back yesterday when saw FS for a scan - my results came back positive for ANA. This means that I have antinuclear antibodies in my blood - these attack my own cells apparently! FS did not give me many details but has said that I will have to be on asprin from the day of the transfer as my blood vessels constrict and so would reduce blood supply making it hard for the embie to implant. I'll also be considered high risk if we get pg. I'm off to see another doctor (non IVF related) at the Royal Melb Hospital on Wed (they were so good and got me in before transfer as initally they were saying they could not get me in till after xmas) to find out more.
Sorry to hear your results (I hope you doing mind me saying that am a little excited for you if this makes sense) but this means you have identified something which is an issue and can be treatable with a different protocol. I have heard of quite a few success stories after this was identified. Will be crossing my fingers and praying for you. Hugs xx
I have just read your March 2009 post in this thread about MTHFR factor and I also saw that you had posted in the high FSH thread as well. I too have high FSH (19) and wondered whether you had managed to lower your FSH as well as doing the new protocol for MTHFR for your pregnancy in June?? Congrats by the way.
I had a BFN after my first IVF cycle in August (down reg) and the FS suggested we do a flare cycle... well today is CD1 and my FSH is too high. So i am waiting for the next cycle I suppose. In the meantime I was interested in MTHFR and am going to ask my FS tomorrow to test me for it. I have had Vitamin tests before though and think they were okay. Not sure. Anyway, it interested me because I googled MTHFR and saw it is related to miscarriages etc and I remembered that my mother and her sister (my aunty) both miscarried their first child (and they were in their early 20's) and I'd completely forgotten to tell my FS of this fact.
Like you i've been tested for most of the other stuff...but i"m pretty sure not this MTHFR factor. I know i've only had one cycle but I just think maybe there's more to it.
Had appointment with specialist yesterday, and have been diagnosed with Antiphospholipid syndrome - which basically means my body attacks the embies before they implant and the interaction with the immune system occurs to allow the pregnancy to progress. Apparenlty the syndrome is also related to reoccurent M/C. So I'm on asprin as of now and then 2 x per day heparin injections from transfer. If we get a BFP than I'm on the injections for the first 16 weeks and then it is reviewed. There is not clear answer on why this treatment does (or in some cases does not work)...but I just hope that this works for us
Selin - wishing you all the best with your pregnancy.
FG
I'm really good at starting threads and forgetting to come back and reply to them....and to be honest I've been really struggling lately with our situation.
I got my test results back in December. A couple things which my doc said aren't major, but added together could potentially have caused problems. I tested positive to the MTHFR gene mutation (which I think makes you more prone to miscarriage?). I've been told to take mega folate and a vitamin b maxi for the rest of my life.
Tested positive for thyroid antibodies, so I need to get checked yearly for thyroid problems.
I'm a bit sketchy on the next bit - there was an 18% result on something which I can't remember, but it was an immunity thing. I'm sure she said it could be immunity, or I could have just had an infection in my uterus at the time. But anyway, as a result when I do the next cycle, I need to take antibiotics, progesterone and aspirin. And if I get pregnant then they'd swap the aspirin for injections for the first trimester.
We haven't attempted another cycle yet. I want to but my husband wants a break. Says he just wants a break from the disappointment. I'm keen to do one asap to see if this new protocol makes any difference, but at the same time I'm not sure I'm ready emotionally for a disappointment either.
I just wanted to say that this thread was really helpful. I have had three failed transfers, and am currently in the TWW for the fourth. Am worried that I might have an issue with implantation. I was thinking of asking our FS about further testing, and now I know exactly what to ask for!
Like many of you have commented, I am frustrated that they do not do this testing up front, but your stories have inspired me to take charge of the process!
Hi ehm - first of all, good luck with the TWW. Fingers crossed for you. Do you know if you have a problem with high FSH? There is a good thread for that as well. And have you considered or are you taking low dose aspirin at all? There is a thread in here for that too. I have posted my story on one of those threads (along with the other girls stories) and there are heaps of ideas on things you can try yourself rather than leaving it all up to the specialist to advise you. Hopefully you won't need it though
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