Hi Lulu, sorry to hear that your stim meds aren't working like you would hope. While I don't have any experience with low response (I responded really well on fairly low doses of Gonal-F), I can comment about the ICSI failure. My first cycle didn't use ICSI and of my 10 eggs, 7 fertilised when they just let DH's little swimmers race for my eggies. Unfortunately our PGD results showed all embies to have chromosomal abnormalities. Our second cycle we used ICSI as we found out that it didn't cost us any extra, and we were told it would increase the rate of fertilisation. That time we got 21 eggs (slightly increased dose of Gonal-F) and after the ICSI only 10 fertilised. I was really shocked. Our first cycle was 70% fertilisation rate "naturally" so I thought the ICSI would increase that, so getting a less than 50% rate was surprising to me. Of our 10 embies all but one had chromosomal abnormalities again, so we've been extremely lucky that our one healthy embryo has implanted and is growing strong.

As for doing a natural cycle, do you know if you definitely ovulate when you are not on the stim meds? If you do, then I guess there would be no difference for you between doing a natural cycle and a stim cycle.

I really hope you have some luck soon and wish you all the best!