IVF with PGD #4

[Sara69]

Julie: Really sorry to hear about the bad time you've had It sounds like it was a great move to change to a new acupunturist, so glad you found someone good. Hope the treatment is working so that you can avoid the D&C.

Nothing new for me, AF isn't due until tomorrow, have some cramping, boobs tender again, very nervous... trying not to walk up walls... you all know the drill ...

Sara

[HotI]

Hi

I don't often post in here, but i have been reading because PGD is something that may be in my future. This recent article came out in the Human Reproduction journal, and i thought you might find it interesting.

Two-year auxological and medical outcome of singletons born after embryo biopsy applied in preimplantation genetic diagnosis or preimplantation genetic screening.
Desmyttere S, De Schepper J, Nekkebroeck J, De Vos A, De Rycke M, Staessen C, Liebaers I, Bonduelle M.
Hum Reprod. 2009 Feb;24(2):470-6. Epub 2008 Dec 2.

BACKGROUND: Embryo biopsy is an essential but invasive procedure to perform preimplantation genetic diagnosis (PGD) or preimplantation genetic screening (PGS). The major objective of this study was to determine whether embryo biopsy might cause post-natal growth restriction.

METHODS: We compared growth data and physical findings at birth and 2 years for singletons born either after PGD/PGS (n = 70), ICSI (n = 70) or natural conception (NC) (n = 70). Children were matched for gender, maternal educational level, mother tongue and birth order.

RESULTS: No significant differences were found between the three groups regarding weight, height and head circumference standard deviation scores (SDS) at birth and at age 2 years, although the PGD/PGS children tended to have a lower birthweight compared with the NC children. At 2 years, the mean BMI SDS in PGD/PGS children was significantly lower compared with NC children (P = 0.005). PGD/PGS children were more frequently born after Caesarian section than ICSI children, but had no more congenital malformations, hospital admissions and surgical interventions compared with ICSI and NC children.

CONCLUSIONS: Singleton children at age 2 years born after embryo biopsy applied in PGD/PGS present a similar post-natal linear growth compared with ICSI and NC children. PGD/PGS singletons appear not to be at higher risk for congenital malformations and surgical interventions during the first 2 years of life. To date, there have been no observable detrimental effects of the PGD/PGS procedure on children.

*If this is not appropriate, please let me know and i can remove it. Kate

[Sara69]

Thank you Kate for posting this interesting study, that is quite reassuring to know.

Sara

[buliej]

Sara - I have my fingers and toes crossed for you! I so hope this is your turn.

[Where there's hope]

Julie - sorry to read about the rotten past few days you have had . I am sure all you want is to move forward rather than have this all linger. I hope your accupuncturist has done the trick. Take care, hun xx

Sara - I have my arms, fingers, legs, toes - EVERYTHING for you, m'dear!

[MsPink]

Julie - so sorry about the last few days you poor thing. I hope your poor crampy uterus has been able to perform so to speak and you can avoid the d&c..

Sara - have been thinking about you all week. All the best for tomorrow sweetie..I truly hope you get good news..

Kel - how wonderful you may already have a possible donor..

[Bengal]

Popping in to wish Sara all the best for today