IVF with PGD # 9

[elle.]

Sunbeam - What a great result!! Such great news! Hope you're still feeling well.

minnie - Yes!! Bring it on!!

Hi to everyone else!

[J.Bear]

Such wonderful news Sunbeam! Have a great Chrissy break all : )

[Sunbeam]

Thanks girls I am super happy with having 17 in the freezer ready for next year. I feel I can have my Christmas break fairly confident there must be at least one good one waiting for me.
I can't wait to see how we all go next year. Bring on the 2013 babies!!!

[babymama23]

Hi guys,

I am very new to all this and to date have been pretty relaxed about it all. I am in my first IVF cycle with PGD to test for hubby's syndrome. I have just had my egg retrieval, and now am all of a sudden nervous that I have been too optimistic (not sure what that is all about).

Does anyone know of any online resources that break down the probabilities of survival of the embrios at each stage (can you tell I'm a numbers girl)?

My fertility nurse is super positive about how we went at retrieval (23 collected, 20 mature, 20 fertilised) but the FS was very reserved. We cant really afford to do this twice so I am really hoping we get a baby and maybe even some spares this round Is that crazy?

Any advice would be great!

Thanks!

[Sunbeam]

Hi Babymama
Welcome to our thread . I'm sure you will be pregnant in no time, these threads have a way of being last in first out!! When is your transfer? I can't really give you any numbers on how many will be affected by hubby's condition unfortunately that depends on how prevalent it is. If you google the condition and pgd you may find some more info. 20 is a great number to be working with though. At your age I don't think the drop of embryos should be too bad as your eggs are pretty fresh. I'm not sure if there are exact stats on drop off rates, I have never seen any, there are so many factors that can affect it. Sorry not much help am I
Good luck.

[babymama23]

Hi Babymama
Welcome to our thread . I'm sure you will be pregnant in no time, these threads have a way of being last in first out!! When is your transfer? I can't really give you any numbers on how many will be affected by hubby's condition unfortunately that depends on how prevalent it is. If you google the condition and pgd you may find some more info. 20 is a great number to be working with though. At your age I don't think the drop of embryos should be too bad as your eggs are pretty fresh. I'm not sure if there are exact stats on drop off rates, I have never seen any, there are so many factors that can affect it. Sorry not much help am I
Good luck.

Thanks Sunbeam! Its reassuring just to hear that 20 is a good start and I have time on my side I don't know what came over me, just got really nervous all of a sudden . Hubby has autosomal dominant condition so 50/50 chance. I guess I am just trying to jump the gun and guestimate how many will make it to biopsy. I'll know on Friday how many they'll freeze, so I'll just have to wait and see.

I am doing a frozen transfer cos we are doing PCR and CGH testing. So wont transfer until Jan or Feb depending on how long it takes my cycle to get back to normal. FS said something about the nasal spray trigger helping with that I think (cant be sure was sedated at the time). I'm kinda glad cos I'm still pretty thrown by the retrieval...not fun

Thanks for the encouragement and advice! I love this forum already

[Sunbeam]

Hi Babymama,
I've never heard of a nasal spray trigger so maybe it's something you dreamed under sedation there again it could be totally real!
Are the clinic updating you each day to how your embryos are doing or do you just have to wait till friday?
I think a FET is much better option given that huge egg haul I'd imagine you won't be feeling so great over the next few days. I was never surprised when I didn't fall pg on a fresh transfer as I always felt so ill after my collection.
Looks like there will be several of us doing transfers in Jan and Feb

[Andie78]

babymama23 - i cant comment on your particular situation, but i can tell you how i went with my first pgd round so you can get an idea of the potential drop off rate. the reason i did pgd was bc i had done 5 stims cycles & 10 transfers with no luck, so we wanted to check out my embryos (i am in the 'unexplained' basket). i got 13 collected, 10 or 11 fertalised, 7 were availalbe for biopsy. out of those 7 biopsied, only 2 were chromosomally normal. i was told that this is what you would expect to see after collecting a batch of eggs. i was happy with this result as i have read (and learnt from the lovely ladies in this thread) that sometimes you can have nothing to transfer. like sunbeam mentioned, its different for everyone... you might be the lucky one that gets 10 normal embryos!
also, i have had the nasal spray trigger for one of my stim cycles before. the fs i was with at the time used it bc i got ohss the previous cycle and the nasal spray trigger is supposed to reduce the risk of ohss. i just used syranel, im assuming this is what your fs might have suggested? anyway, it worked fine and epu/recovery was fine too. i wish you the best of luck, let us know how you go.

sunbeam - hope you have recovered well and looking fwd to your xmas & new year break before your biopsies/transfer in the new year... xx

hi elle, minnie & everyone else.

[babymama23]

Yay! I am feeling good about January so fingers crossed we all have a run of luck Unfortunately the nasal spray trigger (synarel) is very real (yuk!) but better than another bloody jab My FS seems to love the stuff, but I can't really remember why...must be something to do with being full of needles at the time
I was pretty unhappy on ER day, still not 100% and I can feel the meds still screwing me up (very cranky lady). But the FET will be on a completely natural cycle which I like the sound of...it also gives us time to do the CGH testing just in case.
I just had my day 3 call and I have 13x8 cell, 3x 6 cell and 2x2-3 cell embies. the scientist said I can expect 50% to make it to day 5 biopsy, which seems like a massive drop off Has anyone ever had a 2-3 cell day 3er make it to biopsy? Eeek bring on friday!
Sunbeam, I am starting to appreciate what a massive month you had getting 17 in the freezer! You must have had some huge positive karma owed to you
Andy, thanks for sharing your experience. How long did it take for you're chromasome testing (CGH?) to come back? I heard anything from 3 to 10 weeks!!

[minniemouse]

hi babymama and welcome, what a great number you got from your epu ! have you heard how the embryos went today, was biopsy today or were they waiting until day 5 ?

sunbeam: i hope you are feeling ok

andie: how are you going ?

[babymama23]

Thanks Minnie! They are biopsying on day 5 (friday) or 6 and will freeze whichever ones look good after that I think. So nerve racking :S

[elle.]

Hi babymama - Welcome to the forum! I would be super happy with that number. (I had my first cycle in Oct and have only 3 embies frozen from that one, so the next one has to be it for me. My DH and I both carry faulty genes for a recessive condition so we have 25% chance of affected babes). My fingers are crossed those little embies of yours behave themselves and you get some really good results. Best of luck to you! And I hope things are settling down for you now. It's awful to feel so uncomfortable in your own skin, isn't it?!

There definitely looks to be lots of Jan/Feb cycles/transfers happening! Here's to 2013 being our year, ladies!!

[Sunbeam]

Finished work till Jan 14th yay yay yay!!

Babymama - I hope your hormones are settling down for you. Any update on your embies? I hope there a decent few good ones. 13-16 at day 3 is great. My 17 are not yet tested, 13 are only day 1 and 4 are day 3 so there's a long way for them all to go yet! The ones that were frozen on day 3 were from a batch of 8 but when they biopsy they are very fussy and won't test any stragglers, only those that have exactly the right number of cells for that day's expected growth. It's a bit harsh and heart breaking but that is the rules where mine are.
Donor Daddy's CGH test took about 4 or 5 weeks from what I can recall.

Hi elle, minnie and Andie. I hope everyone is feeling ready for Christmas. I'm packing today off to mum and dad's in Airlie tomorrow. Bring on the floating in the pool with a glass of wine in my hand whooooooooo!

[J.Bear]

Hi babymamma23, 20 is a good number to start with. Like Andie said I can't offer any advice on ur situation but in the three cycles I've done I have ended up with one balanced embryo for transfer each time. Our first two cycles we had about 20 collected 13 fert & 11 suitable for biopsy. Our third cycle we had 15 collected & again ended up with one to trf (can't recall how many fert ect) but our issue is my chromosome translocation so I would think my drop off rate would be different to urs. Also we had problems with the dyes used for our testing which effected our numbers on the first cycle. Good luck & I hope that u have a nice big batch to freeze.

Sunbeam enjoy ur break, that pool & wine sounds like a good combo!

babymamma23, Sunbeam, Elle, Andie, Joe, Minnie, BF & all the lovely ladies who are a part if this thread , have a wonder full Christmas with ur loved ones & a happy new year. Thinking of u all always : )

[babymama23]

Hi guys. So we have 7 little miracles all biopsies and safely tucked away in the freezer! Not that they didn't have us worried, on day 5 there were NONE suitable for biopsy. But they came good over night, little champions What a Christmas present! Now we can breathe a little bit and come back to find out the test results in the new year.

Ellie, so sorry to hear about your last attempt. Do you know when your next will be yet?

Sunbeam, they are pretty mean in the culling process! I get that they like to keep their success rates up but sheesh! I had 1 extra that by the sounds of it was really close but not quite to their standards...give the poor little guy a chance

J.Bear oh noooo, that's such a huge affected rate! Sometimes these number make me wonder how anyone gets pregnant naturally!


Have a wonderful Christmas every body, and thank you all for making me feel so welcome and keeping me sane

[minniemouse]

babymama: thats great news, will they let you know in the next few days what you have or will it take them longer to get the results ?

jbear: i was interested to read your post, do you mind me asking about your results,, were they mostly affected by your chromosome issues or other problems as well ?

sunbeam: i hope you are enjoying your time off work !

elle: when are you starting your cycle ?

joe: are you going to be starting fresh again soon ?

andie: are you having another scan soon ? how are you feeling ?

[babymama23]

babymama: thats great news, will they let you know in the next few days what you have or will it take them longer to get the results ?

Hi Minnie. It'll be 3 weeks for them to do the CGH (which they are doing for no specific reason, just to make sure none slip through with chromosome probs that might self abort anyway) so they said they'd come back to us with the PCR results then too. So I'll miss this cycle by like 2 days and come back for implantation (hopefully ) in jan. Does anyone have any suggestions on what I can do in the mean time to get nice and sticky???

[Sunbeam]

babymama - I get put on estrogen tablets for my FET cycles to build up a nice sticky lining (also means they don't have to wiat for me to O which often doesn't happen). 5 dyas before they will also start me on progesterone (so my body thinks I just O'ed). have they said they will do any of this or is it going to be a natural cycle?

AFM- Hasn't stopped raining since I got to Airleie Beach which everyone is very grateful for since they have not had much rain for 4 months, bit miserable for me though (only one swim in the pool so far!!) Supposed to clear out tomorrow though. I hope everyone is having a lovely Christmas time and that Santa is working on bringing us bubs by next year.