NK Cell result back - Very high

[Cuddlepie]

WTH, thanks for the input, that's the first thing my FS said. He said it is not conclusive just to see the b/t result. I did notice Melbel's result, however hers is the other way around. When you say no bearing at all, could there be any possibility that this high level of NK cell present in b/t and none in endometrium?

Its probably a good idea to get the biopsy done and know exactly how big the problem is. Just wondering how different the treatment is? Would the treatment differ depends on the level of the NK cells etc? I am doing some research at the moment and might email Dr. S some questions.

thanks hun

[Where there's hope]

WTH, thanks for the input, that's the first thing my FS said. He said it is not conclusive just to see the b/t result. I did notice Melbel's result, however hers is the other way around. When you say no bearing at all, could there be any possibility that this high level of NK cell present in b/t and none in endometrium?

Its probably a good idea to get the biopsy done and know exactly how big the problem is. Just wondering how different the treatment is? Would the treatment differ depends on the level of the NK cells etc? I am doing some research at the moment and might email Dr. S some questions.

thanks hun

A few thoughts come to mind. First of all, Dr S is the recognised pacesetter in this field. Our friend Meredith flew up to see him and I recall her treatment was based on the BT alone. But yes, I was told by my OB (who is also an FS specialising in recurrent MC) the NK BT result is not a reflection of NK cell levels in the endometrium. This is why the biopsy, rather than the BT, is a part of the recurrent MC Investigation Program. But your BT result seems high so personally I do think you are on to something. It also fits in with your TTC history as a high level of NK cells can affect implantation or cause MC. Perhaps the biopsy would help Dr S/your FS best calculate the optimal dose of prednisone for you. Might also be worth contacting Flowerchild, if you have not already as she was able to help me understand the subject a little better.

BTW - Dr S was also ethically respectful of taking any further steps with me as I am with SIVF, too.

Good luck, Cuddlepie

[Cuddlepie]

Thanks Possoms for your good wishes, I hope you soon work it out what you are going to do for your next cycle hun...

WTH, I guess I am such a bad case and no need for a biopsy, straight to the treatment. Dr.S emailed me said they classify as 'normal, borderline and high' and mine was high, most likely correlated to the endo. biopsy result. Well, at least I can skip that biopsy which I cringe. But always love to hear your thoughts and thanks for always being there for me...

[MeredithD]

CP - I have answered your PM with more info on what treatment I have been on but for anyne else reading this thread I will briefly overview.
I had NK cell test done for recurrent m/c but biology is much the same as per implantation issues - its just at which stage the NK cells really attack the embryo. The other thing to remember, is that levels can vary a lot with time, concurrent illness etc. I questioned Dr S on why I had already managed DS without any diaganosis or treatment. Answer basically is that a) maybe NK cell issues are not the reason for my m/c's b) the problem wasn't as bad during that time c) DS was a particularly strong bubba and managed to "fight back" and keep on sticking
They do think that the NK cells are only really important ( they are actually needed at "normal" levels for correct implanation/placentation) or harmful in the first 12wks or so. After that point they should affect pg to much
Anyway, I only flew up and had the BT ( results around 21% I think) as Dr S thought this result was significant enough to avoid the biopsy , particularly as this would have been difficult for me ( I don't cycle so would have had to do OI just for test)
Dr S was also a bit hesitant with "interfering" to much as I was under another Dr in Melbourne but I was there with her full knowledge and support so he did ease off a bit. He actually reccomened starting the pred at same time as starting IVF stim meds. My first cycle on it, I didn't get pg and weaned over next few weeks but started up again pretty soon with another cycle - this pg.
At 18wks I am now down to 5mg and should be off by 20wks
My most major side effect has been hair loss - losing mountains of hair and starting to become noticeable! Haven't got moonface etc so have been relatively lucky
As for clexane, Dr S said to me he normally only uses pred for NK issues but I had already been using clexane as a trial from my FS ( and had used for DS's pg). Came off it at 8wks after much heavy bleeding and loss of this bubba's twin

I hope your current FS can give you the answers you need CP but as the other's have said, change to Dr S if you are not happy as you really have nothing to lose and he is the "expert" in this field

[MeredithD]

CP - I have answered your PM with more info on what treatment I have been on but for anyne else reading this thread I will briefly overview.
I had NK cell test done for recurrent m/c but biology is much the same as per implantation issues - its just at which stage the NK cells really attack the embryo. The other thing to remember, is that levels can vary a lot with time, concurrent illness etc. I questioned Dr S on why I had already managed DS without any diaganosis or treatment. Answer basically is that a) maybe NK cell issues are not the reason for my m/c's b) the problem wasn't as bad during that time c) DS was a particularly strong bubba and managed to "fight back" and keep on sticking
They do think that the NK cells are only really important ( they are actually needed at "normal" levels for correct implanation/placentation) or harmful in the first 12wks or so. After that point they should affect pg to much
Anyway, I only flew up and had the BT ( results around 21% I think) as Dr S thought this result was significant enough to avoid the biopsy , particularly as this would have been difficult for me ( I don't cycle so would have had to do OI just for test)
Dr S was also a bit hesitant with "interfering" to much as I was under another Dr in Melbourne but I was there with her full knowledge and support so he did ease off a bit. He actually reccomened starting the pred at same time as starting IVF stim meds. My first cycle on it, I didn't get pg and weaned over next few weeks but started up again pretty soon with another cycle - this pg.
At 18wks I am now down to 5mg and should be off by 20wks
My most major side effect has been hair loss - losing mountains of hair and starting to become noticeable! Haven't got moonface etc so have been relatively lucky
As for clexane, Dr S said to me he normally only uses pred for NK issues but I had already been using clexane as a trial from my FS ( and had used for DS's pg). Came off it at 8wks after much heavy bleeding and loss of this bubba's twin

I hope your current FS can give you the answers you need CP but as the other's have said, change to Dr S if you are not happy as you really have nothing to lose and he is the "expert" in this field

[Where there's hope]

Hi Cuddlepie

Sounds like you have an action plan with the assured confidence of Dr S . I really hope this is the turn-around you need to get that lovely little frostie of yours on board and thriving.

Take care, hun

[Cuddlepie]

Thank you so much Meredith for sharing your journey....I am sure it will also give anyone who is interested in this topic a great heads up...

Currently I am on my D5 on FSH, and going to push FS this Friday when I see him to put me on Prednisone straight away, as I had an impression that you don't start the meds until Transfer. It might be for the mild sufferers, but I think in my case, the earlier the better to regulate those NK cells, stop attacking my beautiful embies Please!

[Possums]

good luck with that CP