Hi India,
I don't think clomid interfers with opks at all. I haven't ever had any success with opks myself, but then I may not have O'd on the cycles I used them. I never had a positive reading.
But, did you know that OPKs can sometimes give a +ve result if you are pg? Have you done a HPT? With the symtoms you are describing I would be doing a HPT. Good luck