MrsP - something to ask your Dr is if the three doses need to be exactly evenly spaced? I did 3 crinone/day for my last IVF and my Dr wasn't worried about evenly spacing them out (probably because we had only done 2/day previously so the third was an "extra"). I did my first before leaving for work, my second as soon as I got home from work and my third just before bed. I think they usually ended up being about 6am, 4-5pm (I usually work 7.30-3.30ish), and 9-10pm. Seemed to work just fine, but I'm not sure if the timing would be more important for the pessaries?