Danni - I started out on 125iu, then dropped to 75iu after the first week or so, because I was responding too well! It really didn't hurt at all - I was surprised at how easy jabbing myself in my soft tender belly turned out to be. My biggest hint - make sure your thumb is on the end of the pen BEFORE you put the needle in, otherwise it's a bit awkward trying to rearrange your hand when the needle is already in your belly.
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