We had our own cut off for choosing an amino/cvs or not. Which was around 1:250 or 1:300 T21 risk, as the statistical risk given for m/c after amino is about 1:250. After the losses we had, we didn't want to risk a m/c. If you choose a good consultant OB who does them all the time, the risk should be lower.

We had a good result for both boys, so didn't want to take the risk. It was the 20wk scan we found out DS2 was sick and had an amnio a couple of weeks later. He was chromosomally normal but had a separate, fatal condition. The amnio was stressful and painful, but quick and I just breathed through it.

If you're happy with the 1:350 risk, then I wouldn't do it just for your OB. You may want to have a scan at 16wks to check things like the heart before making the decision. Or you could choose to wait to the 20wk scan.

Also, with an amnio, they can check for spina bifida, which they can't with a CVS, if it comes to a choice.

Btw - what was the NT measurement? According to the OB that did the NT on DS1, the blood work accounts for 10% of the result. So if the NT measurement is good but the blood work skews it, you may want to take that into account.

As for termination, if someone wants to have a go, I will not be happy at all. If you find out and choose to terminate in the next few weeks, a D&E is possible. It's when you get closer to 16-18 weeks that birth becomes the safer choice.

Everything is your choice. It's your body, your baby. We make the best decisions for our children with the information we have at hand. Take care.