For DS1 I had a 1 in 350 risk and I was only 27. I didn't even consider an amnio as I know for sure I would not terminate and i didn't want to risk a miscarriage.

A friend ha a 1 in 10 risk of Downs and other conditions. They had also a cleft palate. The OB wanted her to do a Amnio as it would make his job and the paed's job easier if they knew what they were going to be dealing with when the baby was born. My friend said tough and didn't get the CVS.

A friend from mothers group chose to do a CVS and she started leaking fluid (despite it being performed by the best specialist for this procedure in our city). She said she lost her tummy and was on bed rest for a week. The pregnancy is continuing so far and the CVS was clear. I just can't imagine her grief if she'd lost her baby.