Hun, does he have blood tests to make sure that his liver and kidney function is OK? MTX isn't a drug you take lightheartedly. It can do serious and irreperable damage if not taken under strict monitoring. I had to have a blood test once a month to make sure that all my levels were fine. I just had an appointment on Tuesday and I am allowed to have a break from it to see how it goes without the MTX and I couldn't be happier to be off it, you aren't even supposed to drink alcohol because of the extra burden it places on an already stressed liver.