Genetic testing for breast cancer?

[AnyDream]

Mak - I'm having a mastectomy (one boob only) later this year so I'm like a woman obsessed right now! LOL

[Mak]

Completely understandable!!! I have seen some great reconstructions, you would never even guess - it is so different now to what most people imagine (usually based on horror stories from 20 years ago).
Thanks for sharing your expertise with everyone! I wish you a speedy and uncomplicated recovery later in the year.

[~clover~]

Thankyou guys for all of that. I didn't consider a masectomy, but its given me more to think about if I am genetically likely to get it. & its great to hear about implants too...it kind of scared me when I first read that you would do it megiemoppet. It would by far be the best answer, but the thought of doing it myself...I don't know.

It was my paternal grandmother & she only had 3 sons, so its kind of hard to determine just from family history repeating iykwim. My sister already has some AF related problems that are similar to what Grandma had, but we really know nothing about it. Pop won't speak about it & I really don't think they'd have had much Idea anyway. It was the 50s/60s, so not sure what they really knew back then. The only reason we know there were problems of that kind is because for some reason Pop blames Dad. (Her 2nd born.) I don't know if that means it started after he was born or what...there's never been any sort of explanation.

So I'd have to wait til after I finish BFing. OK, cool.

Bath - I like your bigger boobie idea I shouldn't complain being a C, but I have a feeling most of that's milk

MD - Thankyou for your personal insight. I really hope all goes well for you!!

[lilima]

Also to add, my mum has had double implants done, and has had the nipple reconstruction and the tatooing, and it looks SO good. You can't even tell they are fake.

I suppose seeing my mum and aunt so sick with chemo etc has made my decision easy. I am not that attached to my boobs, and in all honesty, they are saggy baggy now that I have been breastfeeding! Mum really loves that she now has nice boobs, so she has influenced in how I think.

[HotI]

Hi

In order to have genetic testing, you need to have strong family history of breast cancer or associated cancers. Only 5-10% of breast and ovarian cancers are caused by mutations in the 'breast cancer genes' BRCA1 and BRCA2.

These criteria can be used by GPs to work out whether a woman should be referred to a genetics clinic to see if genetic testing is appropriate:

# Have a close relative (parents, grandparents, children, grandchildren) with a known mutation in BRCA1 or BRCA2

# Have close relatives across more than one generation (for example, a mother and a sister) that have been diagnosed with early-onset (before age 50) breast and/or ovarian cancer

# Have an individual family member who was diagnosed with both breast and ovarian cancer

# Have had cancer in both breasts, especially if one or both cancers were discovered prior to age 50

# Are of Ashkenazi Jewish heritage with breast cancer before age 50 or ovarian cancer at any age

# Have a male family member with breast cancer

# Have other associated cancers/conditions

Testing usually begins with the affected person (someone who has, or has had a cancer associated with BRCA1 or BRCA2). If a mutation is found, then other family members can be tested. If a family meets the criteria (of being at high risk) then genetic testing can be provided at no cost.

Surveillance is really important for all women, as breast cancer is so common. Regular breast checks, even getting your GP to perform a check, can help pick up lumps early. And the earlier cancer is detected, the higher your chances of recovery,

[~clover~]

Thanks Kate
So how would I tell if I'm high risk? Since Grandma only had 3 boys & she has already passed?
She was under 50 when diagnosed. She did end up with cancer in both breasts & a double masectomy, but the second wasn't til I was in my teens...the first when I was very young. Because it spread so far through her body, there is every chance ovarian was involved...she did have it in her stomach & other places over the years. I haven't heard though.

[HotI]

Thanks Kate
So how would I tell if I'm high risk? Since Grandma only had 3 boys & she has already passed?

It can be more difficult to gather all the information when a relative is no longer around.

Do you know anything about your Grandma's brothers, sisters, cousins or their kids? Did any of the develop cancer?

How many kids did the 3 boys have? How many girls/boys? Is there any cancer in any of your cousins?

All of this information can help to assess your risk.

If your grandma is the only family member who had breast cancer, your risk would only be at or slightly above average risk. This is the risk given to 95% of the female population and gives a lifetime risk of breast cancer between 1 in 11 and 1 in 8. (More than 90% of women in this group will not develop cancer).

[~clover~]

Ok, will ask about her relo's. I really don't know.
All my cousins are younger than me, so no cancer yet. The other girls are 22, 19, 12 & the boys are all younger.
I should be able to find out. I'm sure mum said she wants it done because there is family history, but didn't say how. I'm sure there was more than just Grandma though.
A cousin had cancer, we lost her at 32, but she was on pop's side, so doesn't count. And it was in her stomach as far as I know...