Colleeg - I too get pretty bad indigestion and it is getting worse. It mainly hits at night and wakes me up. Not a very pleasant thing to wake up to! Up until now, quick-eze have worked well enough but I am finding that the heartburn is breaking through somewhat. I might ask my Dr. about Zantac to help it out a little. Like the others have said, they wouldn't prescribe it if it wasn't ok to take. I find they are pretty cautious about just about everything. Hope it clears it up for you!