As PP have said, the screening odds are good for her age. She could wait until the morphology scan, realising that scans are not diagnostic and things can be missed. She may want to talk to a genetic counsellor for advice. She can have an amnio anytime up to birth. In Victoria, it is legal to terminate anytime up to birth, based on approval by a tertiary hospital ethics board. Note, that if she chose to terminate after the morphology scan, she would most likely have to birth the baby. Up to about 16 weeks, she could have a D&E.

Firstly, she needs to think about whether or not she would continue a pregnancy if the baby had T21. There is no right or wrong answer there. she may want to talk to people about what it actually means. Whilst some people with DS, especially mosaic DS, are high functioning, most have ongoing physical and mental health problems. Which is why I suggest she talk to a genetic counsellor. They're trained to help people make the best decision for their family.

If she chooses to have an amnio, the genetic counsellor may be able to guarantee a more experienced doctor to do it. Otherwise, there are a number of very good OB specialists who are expert in it. Their risks are lower than the general 1%.

As an FYI, both my boys were chromosomally normal and had different fatal conditions. Both had great NT scan results and one had a normal morphology scan. The NT scan is not the be all and end all. It is just one indicator and the accuracy differs depending on who is doing it.

If she needs to know either way for peace of mind, then I'd get an amnio. If she wouldn't terminate but would like to be prepared if the baby has DS, I'd get an amnio. If the fear of miscarriage outweighs the fear of DS, then I wouldn't get it.

I've had an amnio. It hurt and I found it stressful, but we already knew DS2 was sick. It didn't hurt him and it was over quickly.

I'd tell her to take time to process everything, do some research, talk to a genetic counsellor and then make the decision.