Im 11w pg and suffering quite badly with what I suspect is a bit more than just ordinary m/s, so a bit of ginger and small meals, etc dont help.

Im on 16mg of Zofran a day, 8mg in the morning which seems to be effective for a couple of hours. Then 8mg in the afternoon which seems to do absolutely nothing apart from slightly reducing the number of vomiting episodes, but not enough to make a difference. The nausea is extreme during the afternoon/evening and my body tends to heat up so I feel very feverish (this happened before I took zofran too, so not a side effect). Nothing I try seems to help and its really getting me down. All I do is lie in my bed with a cold compress to cool me down, sometimes in the dark because light seems to make it worse, especially at night after 6pm. I havent gone to hospital because Im able to drink quite a bit of water and eat almost normally during the morning and lunch, so although I am somewhat dehydrated, I can re-hydrate myself n the morning.

So my questions - I thought zofran would help but it doesnt even touch the nausea in the afternoon/night. Is this normal? Did Zofran work for you and if so what dosage were you on? Also, what did you take to relieve the terrible constipation it causes (TMI warning - Its been 9 days since my last BM and I took metamucil yesterday with no luck).