Yes, the chance of having a child with DS does increase with maternal age especially. I was 38 when I was first pg and the combined NT and bloods gave me good odds. I was really scared of the amnio in case I miscarried, especially as we've had to resort to IVF. With my second pg at 39, I did the same thing, and the combined results were still good. It's totally up to you hun, I went with what my doc recommended. Being well informed and educated has great advantages.