Pg after LT TTC - What did you do differently?

[grub17]

hi hope this helps you:

I'm very fit and was regularly running 8 to 10kms a day.

Our first cycle the drugs made me sooo tired that i spent the whole time sleeping and didn't exercise. It was BFN - but that's pretty common on the first go as they are just sorting out your body's response to the drugs. we had high expectations and were shattered when it ended in nothing. We got 1 fresh and 1 frozen egg that cycle.

our FET was also unsuccessful a few months later, again got over excited and kept ''feeling'' all sorts of things i thought were a pregnancy. nope!

our second full cycle - i was determined to get on with life as normal and not spend so much time thinking about it all. I kept up my running, in fact increased the mileage, right up to the collection date and then another long on the monring of the transfer.

I firmly believe all this lovely oxygenated blood going through my system helped me get better eggs and more of them than before. We got 3 eggs (blasties) this cycle and the first one (fresh transfer) is now all snuggled up asleep in his basinette (and he's perfect by the way).

I also took a more positive approach - a what will be will be. kept saying: "i can't change anything'' so need to accept its out of my control.

hOpe that helps you and i hope your dream of a baby comes true.

ox

[Persephone1]

It was no "one" thing for us, (at least not one thing I can point to) but we did do:

1. weekly acupuncture for 4 months leading up to the BFP, including treatments on the day or around the time of the transfer; and
2. We'd had 6 single, day 2 embryo transfers and all were BFNs. On this cycle we transferred 2, 5-day embryos. Only one embryo stuck.

We had never tried transferring blasts, and I barely thought much of it, except that a friend of mine had done some research and told me that blasts are more successful because they are transferred into the uterus at the time that a 'naturally conceived' embryo would have arrived in the uterus. Day 2 embryos are transferred into the uterus, but 'naturally conceived' Day 2 embryos are still somewhere in the fallopian tube, so the environment in the uterus can sometimes not be "ready" for an embryo. Hope that made sense.

We were treated for male-factor infertility only, although I have polycystic ovaries (the polycysts, not the syndrome). Day 5 embryos were a good try for us because it's after Day 3 that the spermies really start to work hard - Day 2 embryos might look good, but the sperm hasn't started doing it's job yet. If an embryo lasts after Day 3 then they can tell that the sperm seems to be doing okay.

Good luck.

[xx Rob xx]

I forgot the one clinical thing that was different. I will apologise for TMI straight up.

The first cycle we used DH sperm that he had ejeculated. We tranferred 1 and froze 5. When we thawed the 5 none survived the thaw.

The second cycle we used TESA/PESA as in a neddle to get the sperm. We transffered 2 that didn't work, although I did had mild OHS. We later did an FET and thawed 2 and they both survived thus we transferred two resulting in a BFP.

[JustOneMore]

[JustOneMore]

CeCe and Loula,

Re: Prednisilone and Clexane

I had tests with my previous FS as I constantly failed to implant. Nothing of note came up on my tests. My new FS prescribed the prednisone and clexane as she had success with a few other ladies in a similar situation to me and thought I may be in the same 'weird' group as them - meaning there is no real explaination as to why it would work.

I was prescribed clexane 40mg which if I recall correctly I started the day after ovulation, and prednisone 10mg. I think I started this earlier but can't really recall. Both of these were taken at night.

same all my test returned normal but due to so many losses and so many cycles my FS put me on both these drugs for the last 4 cycles and i got a BFP with them all but MC. the last cycle my clexane was increased to 40 mg from 20mg but i have had to reduce again due to bleeding

Do you remember when you first started taking Prednisilone ?
How long are you on Prednisilone for ?
When do you stop taken it or do you stay on it through the entire pregnancy.
Did you have any side effects ?
CeCe you mentioned you are on 10mg a day, Loula what was your dosage a day ?
Did you ladies have to increase your dosage or did you stay on the same dosage ?

Thanks again ladies.

[CeCe]

Do you remember when you first started taking Prednisilone ? No sorry, and I can't find the piece of paper it was written on, but I think it was shortly after ovulation.
How long are you on Prednisilone for ? I was 11 weeks on Friday and starting to wean of the pred from Monday. From Monday I take 5mg daily, the following week I take 2.5mg daily and the following I take 2.5mg every second day and stop after a week.
Did you have any side effects ? I didn't have any side effects that I noticed.
Did you ladies have to increase your dosage or did you stay on the same dosage ? I stayed on the same dose I started on, until Monday when I start to decrease.

HTH.

[Loula]

Do you remember when you first started taking Prednisilone ?
I started day after EPU along with antibiotics
How long are you on Prednisilone for ?
starting to wean at 13 weeks
When do you stop taken it or do you stay on it through the entire pregnancy.
see above
Did you have any side effects ?
hunger! lol
Loula what was your dosage a day ?
20 mg and 40 mg clexane recently reduced to 20mg due to bleeding
Did you ladies have to increase your dosage or did you stay on the same dosage
? i think ive answered this one

[JustOneMore]

Just wanted to thank you, CeCe and Loula for answering my question regarding Prednisilone, I appreciate it heaps.

I noticed that this thread has had over 500 views which is great and I hope all this information will help someone some day.

[Hollybolly]

Hi Danyelle,

I know you sent me a PM a little while ago with a link to this thread, so I apologise for taking so long to reply

My issues were a little different to most, so what helped me may not have anything to do with helping someone else with different issues to mine - but I'll post what I think is relevant

Basically we did 6 IVF stim cycles... we always had embies that grew to blast but only ever enough to put 2 good ones back, and the rest were never good enough to freeze.

Cycle #1 - 4 - Were done with a local clinic & FS that really didn't look into any issues as major problems (everything had the 'oh you'll be fine, you've already had a son naturally' attitude).
After 4 failed stim cycles & no glimmer of any changes, I did a stack of research on FS (especially those that dealt with recurring implantation failure) - found one & made an appointment.
He diagnosed what he thought was the issues straight away (my tubes were ruined- which I knew, but he believed they were dripping toxin in to my uterus, therefore expelling any embryos before they had a chance to implant).
So he advised to remove the tubes - I had that done about 10 days after my appointment with him (Dec 2008).
Did our first stim cycle with him in June 2009 - great results although I started bleeding way too early - had my progesterone checked & it was ridiculously low... too low for the embies to have had a chance to implant. (This was an issue in previous cycles, but my last clinic had failed to put it in my file )

SO - stim cycle #6 August 2009 (the current pregnancy), what we did;

* Antagonist cycle - had pregnyl boosters throughout to help with the progesterone level, along with double the usual pessaries, twice a day.
We also used the drug Luveris to help with egg quality.
For the first time in any of my cycles, I asked to have a day 2 transfer - I've only ever had day 5-6 blasts.
FS was hesitant, but I was persistant - so to compromise, we put two back in at day 2 & grew the rest to blast.
The others all grew to blast but had a little too much fragmentation to freeze - from the 2 put back, one took & my little IVF miracle baby boy is currently 23 weeks growing.

* Along with the medicated cycle, I had weekly acupuncture sessions & had all of my levels checked (iron, iodine, etc etc) - and was on a heap of vitamins depending on what the naturopath said my body was needing. (Along with Blackmores conception tablets).
I also took fresh royal jelly from the beginning of the cycle until I got my BFP & levels had risen enough to get to the first scan (6 weeks).
DH took royal jelly tablets, as I knew he wouldn't take the fresh stuff... it doesn't taste that fabulous
He also took whatever vitamins the naturopath prescribed... along with menevit from about 3 months beforehand until the day of our BFP.
I also had acupuncture immediately after EPU & then both immediately before & immediately after transfer.

I think thats about it - my issue was mostly with an undiagnosed issue with my tubes, so I'd like to believe it would have happened before a 6th cycle had I been seeing a decent FS previously

The only thing differently I'll do for next time is to ask for all embies to be frozen at day 2 instead of growing to blast - but everything else I'll do the same as cycle #6.

Good luck, and sorry this post is sooo long!

[barney]

hi danyelle,
i to apolagize for taking so long to get back to you hunny,
we have done 3 full stim cycles 2 ended in ectopics,with our ivf # 3 we had enough embies to do a second FET so we had a day 3 ..3 CELL EMBIE AND A 4 CELL BADLY FRAGMENTED EMBIE PUT BACK low and behold we ended up getting a bfp i did not do one thing different this time ,still just took my vitamins and also took beroca once a day i promised my self this time i wasnt going to wrap myself in cotton wool and did everything as i normally would in fact i worked very hard at my mums pool and aquatic centre cleaning tiolets,vacuming floors anyway worked like a dog this led to my bfp.
one thing i did do though was talk to myself in my own head saying "I CAN DO THIS" evey time i though bad thoughts id say " NAH NAH NAH NAH in my head lol..
so maybe being a bit more positive can help .
i wish you all the luk in the world sweety,one thing i would say is please never give up,this journey is so dam hard sometimes there was many times i would just cry and say i cant do this any more BUT we never stopped trying just remeber hun GOOD THINGS COME TO THOSES WHO WAIT ... hang in there and just keep trying.
ill be lurking on you from now on to see how things go ok take care and again dont give up hunny.

[farmgirl77]

Hi,
For us, it was being tested for reasons for implantation failure and finding out that I had antinuclear antibodies (ANA) which was stopping our little embies from sticking. As we were only a week out from a FET when we found out, I started aspirin straight away and then heparin injections from the day of transfer. We got our BFP from that FET after two failed cycles/fresh transfers and 3 FET's.

Good luck.
FG

[Baby Dreamtime]

Hi Danyelle, thanks for your PM, here are my details:

In total, 10 cycles, 7 transfers and 1 IUI to get a BFP.

Unexplained infertility
Oct 07 BTs Day 2 FSH level 12.
Nov 07 Cycle #1 IVF down reg FSH 225, overstimmed, 20+ follies, cycle cancelled at day 8 as E2 levels were 25,000
Feb 08 Cycle #2 IVF down reg FSH 125, overstimmed, 20 + follies, EPU only, E2 at day 12 was 22,000, 19 eggs retrieved, 15 fertilised all frozen Day 1
May 08 Cycle #3 FET HRT, 1 x Day 3, 6 cell embie with moderate fragmentation. BFN
Jun 08 Cycle #4 FET HRT, 2 x Day 3, 5 and 6 cell embies with moderate fragmentation. BFN
Jul/Aug 08 Cycle #5 FET HRT, 2 x Day 5, 7 cell embies with moderate fragmentation. BFN. Out of frosties, they all seemed to be slow growing with fragmentation, maybe crappy due to high E2 levels at EPU?
Sep/Oct 08 Cycle #6 IVF down reg FSH 75, upped to FSH 100, 19 follies, 12 eggs, 9 fertilised, 3 blasts, 2 transferred, 1 frozen. BFN
FS ordered implantation failure and immunological blood tests, all clear. Decided to try Colorado Protocol anyway.
Dec 08/Jan 09 Cycle #7 IVF down reg Colorado Protocol (Prednisone and Augmentin for 5 days from trigger) FSH 100, 20 follies, 16 eggs, 7 fertilised, 4 blasts, 2 transferred, 2 frozen. BFN
FS referred me to Dr Julie Lindstrom at City Fertility Brisbane as he felt he had done all he could for me.
Jan 09 Met Julie, some implantation failure blood tests missing, new tests done, tested positive for MTHFR. Now on low dose aspirin daily for life, mega folate (5mg) daily for life and high dose B6 and B12. Recommended Clexane from ET or from postive BT (I pushed Julie for Clexane from ET as I had never gotten to BFP before). Continued to take Prednisone while not cycling at 6.25mg per day (quarter tablet) in case of NK Cells (though tested neg on BT, I never did a biopsy but Julie was happy for me to continue). Also tested thyroid levels, TSH, T3 and T4, they were a little off so took thyroid support.
Mar 09 Cycle #8 FET natural, 2 x average blasts transferred, Clexane from ET. BFN
Apr 09 Cycle #9 IVF antagonist cycle FSH 75, too low, 3 lead follies, converted to IUI. BFN but low hcg 9 and prog levels high, possible chemical pregnancy. I had sneakily done Clexane every second day from O day, I think this might have made a difference. Julie hadn't recommeded Clexane as it was not an ET.
May/Jun 09 Cycle #10 IVF antagonist cycle FSH 100, 20+ follies, 23 eggs, 14 fertilised with assisted hatching, 3 blasts, 2 transferred (1 hatching blast rated 10/10, 1 early blast rated 7/10), 1 frozen. Clexane from night of EPU. BFP.

What did I do differently?
Low dose aspirin, mega folate, B6 and B12 for MTHFR
Clexane from night of EPU (my thought was that by a Day 5 ET, it was a little too late).
Prednisone - I had 25mg tablets, CD1 to trigger quarter tablet (6.25mg), from trigger for 5 days (full tablet 25mg), then from there half tablet (12.5mg - in previous cycles I had dropped back to 6.25mg) - I had been on Prednisone since Jan 09.
I did assisted hatching for the first time, I had previously never had a hatching blastie.
This was the only cycle that I did NOT use Embryo Glue
This was the only cycle that I did NOT do acupuncture the day of ET, I had 1 treatment the afternoon of the day after (weekly treatments in the lead up).
I stopped taking Sharkey's herbs in Feb 09 after being on them for two years.
And the only cycle I had no caffeine at all from from CD1

I think it was a combination of treating MTHFR for a few months, being on Prednisone for a while, starting Clexane from night of EPU (my FS had said day after EPU), low dose aspirin, getting my TSH levels right, and nice hatching blasts.

I did self medicate by staying on the Prednisone between my Dec/Jan cycle and meeting Julie, she was of the opinion that I could test for NK cells via biopsy, if positive would then be treated with Prednisone, as I had very little reaction to taking it, she was happy for me to continue regardless. I did sneakily do Clexane injections earlier than Julie recommended a couple of times , and I stayed on low dose aspirin for pretty much the entire time except for a few days before EPU.

I hope this helps, sorry for the long post, please note I don't recommend self medicating, but I was willing to push the boundaries a bit because of my history. There are risks with doing this. But if I have to do this again I will push for the exact same cycle. I wish you all the best. xx

[Bridget]

Hi there everyone

My infertility was also "unexplained" to some degree although I did also have endometriosis and submucosal fibroids (removed about 9 months before I conceived).

What did I do differently with transfer no 10 (embryo no 12 and 13)? I certainly don't think it was anything in my mind that made a difference, I'd had cycles where I was relaxed and positive and cycles where I wasn't and it didnt' seem to make any difference. I had given up on acupuncture (it costs a lot). I didn't have any more rest than other cycles.

I took a bit of a scatter gun approach and kept trying new things like different cylces and pushing for things (it was me who pushed for a laparoscopy the year before during which they found the endo and fibroids).

The cycle that worked I did 3 key medical things. Firstly, the month before I had an injection of B12 from a GP (I managed to convince the GP I might be low because I have some funny blood test results and it wasn't any harm because your body gets rid of any excess anyway).

Secondly, I took prednisolone and clexane. It was the first cycle that I had done that. The clexane was 40g (mg?) and the prednisolone was 20mg per day. I stopped the clexane at about 9 weeks preggas due to some bleeding and I weaned off the prednisolone at 13 weeks. The only side effects I had from the prednisolone were good ones (my ezcema cleared, my asthma was better, my sinuses cleard -I could smell for the first time in years).

Thirdly, I looked back through various test results and found I was positive for something called ureaplasma urealyticum. I asked my FS to treat it with antibiotics. Most FS don't believe it causes infertility but I found some google articles linking it. My FS only agreed to treat because it can cause preterm labour if you do get pregnant.

See - I told you it was a scatter gun approach, not sure which of these things helped but my gut says it was the prednisolone. It took me a long time to convince my FS to try prednisolone. Also, I do want to say that of all my egg collections, this one was probably the worst. All but two embryos keeled over before day 2 and one of those wasn't very good so we put back both on day 2 (compared to other cycles where I'd had 4 or 5 blastocysts). Just goes to show, only takes one.

[mummyintraining]

Hi Danyelle,

I got my very first BFP yesterday morning. It's my 43rd cycle, we started trying in Jan 2007, so I share your pain.

Because we live in a remote area, I resisted IVF etc after being assured by GPs that I was physically healthy and that my partner was physically healthy. We decided to just focus on a healthy, non-toxic lifestyle and keep trying. In December I finally gave in and went to a fertility clinic, expecting to be told to start IVF or that something was drastically wrong. I was diagnosed with PCOS and put on Clomid to encourage egg production. My acupuncturist supported this by supplying me with herbs, supplements and dietary guidelines for PCOS. I have to stress, I could not have done this without my acupuncturist. I was eating so many things that antagonise PCOS, and I had no idea. Without her expert help, I would have sabotaged the Clomid each cycle by eating and drinking all the myriad things that aggravate PCOS.

This month is the 5th month I've followed a fairly strict diet of low gluten, zero soy, low dairy and zero processed foods. Previously I'd been allowing myself 3-4 alcoholic drinks in the week of my AF, sometimes in the week before ovulation, just to reward myself and stay sane, but this time I avoided all alcohol until the night before I ovulated, when I had one glass of champagne. I did this in homage to my many girlfriends who got knocked up after a big night out on the booze. I figured every little bit of luck helps!

I had acupuncture three days before I ovulated and again two days after. I was given chinese herbs that help with implantation, which I took every second day instead of every day after ovulation, which is what I was instructed to do. I know it's bad to experiment like that, but I was following a gut instinct. I also walked regularly during the week prior and during ovulation - I had endess amounts of energy and felt a strong urge to do this (I don't exercise regularly), so I'm wondering if my body was taking charge to otimise blood flow. One thing I noticed this cycle is that my body was really talking to me - everything was functioning well and I was getting very clear signals and urges to walk faster and longer or eat more spinach or don't take that herb. It was very weird.

This time my DH and I did not BD everyday for 5 days before ovulation. This time we BD'd 5 days before, then three days before, then twice on the day of ovulation. Each time I kept my hips in the air for a minimum of thirty minutes, and made sure I ogs'd only after my DH had ej'd, which is something we were not religious on before this.

Other than those minor changes, I obsessed and worried and stressed and thought negative thoughts just as much as I did the other 42 times - I don't buy into "relaxing" as the reason for finally falling pregnant, and it's the number one thing that irritates me when family or friends say, 'stop thinking about it and it will happen'. Honestly, I think any LT TTCer is fibbing just a little bit when they say they weren't thinking about possibly maybe perhaps falling pregnant!

Good luck with your own journey Danyelle, I hope the stork finds your house soon. xox

[tammaspice]

Hello,

I was pregnant last year on my first FET but sadly had a missed miscarriage. That cycle I did acupuncture for a few weeks before the transfer, then on the morning off the transfer then not for 2wks as my acupuncture guy was away and we got a BFP... sadly it wasn't meant to be.

The next 3 FET cycles I did the acupuncture before on the morning of the transfer then a few days later and got a BFN.

Last cycle I thought I'd try something different and did the acup****ure as usual for a few weeks before then on the morning off then thought as it worked first pregnancy didnt do it again for 2wks and we a a BFP!

However I did also take 5 brazil nuts a day from day before transfer to day 5 after transfer (generally in the arvo) and bought a pineapple and cut 1/5 off it each day over 5 days and ate it all (the core wasn't the easiest and had to be spat out a few times) at night for dessert and I also had 100% Sunraysia pineapple juice - 1 glass in the morning. Not sure if this was the clencher for getting a positive but I'm 8wks today and was told last week I had a strong u/sound so here's hoping it continues to stick...

The brazil nuts and pineapple juice assist in getting a strong implantation I've heard so figured I'd try it and the one cycle we did it worked!!! Don't do it earlier than 1 day before embryo transfer or more than 5 days later as it can then turn your lining too acidic which is bad for the embryo...

Oh and I took 2mths off work to destress from my stressful job and hope that helps. Certainly not something everyone can do and it did stuff our finances around but I found after 3wks that I was totally relaxed and by the time the FET happened I was work? what work? ha ha. I have a very stressful job so I think going stress free for a while certainly helped me out. Now to remain stressfree as possible now back at work so I don't miscarry again... lots of prayers happening here and taking it as easy as I can do!

Hope it all works out for you and your friend's sister.

Tammaspice xo