While there is no cure for arthrogryposis, symptoms and deformities may still be alleviated with various methods due to multiple contractures and weakness. Early vigorous physical therapy to stretch contractures is very important in improving joint motion and avoiding muscle atrophy. Patients with amyoplasia or distal arthrogryposis respond well to physical therapy with excellent functional outcome. Splints can also help stretch joints, especially at night. Orthopedic surgery may also be able to relieve or correct joint problems. Joint manipulation during the first few months of life may produce considerable improvement. Orthotics may help. Wrist flexion deformities may be treated with tendon transfers and bony procedures to change the alignment of the wrist. Surgery may be needed later to align the angle of ankylosis, but mobility is rarely enhanced.