All righty, I have read way too much information about reflux meds .

Here goes...

Infants break down losec 3-4 times faster than adults, so need a comparatively larger dose weight for weight. This means that the dose can sound quite high, but may actually appropriate. A lot of people break the dose down into 2-3 times a day for this reason, to get a more sustained effect.

I give DS dissolved tablets too. You need to give them on an empty stomach 30-60 minutes before a decent sized feed for them to be effective. Pretty tall order! DS gets his the second the clock hits the thirty minute mark. The idea is that the little beads need to make it to the intestine unscathed by the stomach acid, then be absorbed into the blood stream ready to attach to the acid pumps while they are working. The bigger the feed, the more acid pumps activated. Each bead is actually drug in a protective coating. Crushing it destroys the coating, thus using it dissolved. I think (?) the suspension isn't as finicky but then you have cost and stability issues.

If you use the dissolved tablets, taking either mylanta or zantac within 4 hours will diminish the effect. For the suspension I think you only need one hour.

Medications like losec do tend to take 2 weeks (in an effective dose) to be effective in babies, though I don't know why. If things with your bub are still suspicious for silent reflux then a trial of a higher dose is probably worthwhile to make sure that the dose being too low isn't why you aren't seeing an improvement.

Good luck, and I hope I haven't baffled you too much! Like I said, I've found way too much info on losec...

And while I'm at it (I hope nobody minds!) zantac is a very weight sensitive medication, so bubs do tend to outgrow their dose. Worth bearing in mind if it seems to lose its effect.