Not sure about Zoloft and TTC, but I have just come off a trial with Zoloft and have found it quite easy...haven't noticed any nasty side effects like I had read about in the pamphlets etc.

I am not a professional so I am just talking from my gut instinct here, but I think if it were me I would come off it sooner rather than later to find out if it will cause problems before ttc, so that any problems can be dealt with and pave the way for hassle free ttc.

Check out the depression and anxiety threads. I haven't been in there for a while because this chapter of my life hasn't been a huge one, so I am probably not the best person to be sprouting my opinion about the place, but there are plenty of girls there who would be able to offer some advice.

My brother was on Zoloft for a while and found it a bit strange to come off as far as physical effects went, but they were very short term, that is why I am thinking it might be best to get it over and done with and just keep an eye on whether you really are READY to come off the Zoloft. In some ways I think there is only one way to find out, provided that it is supervised by a medical practitioner.