i will be honest - the needle is bigger for orgalutran than puregon, so you can feel it more, but i wouldnt say it hurts. you need a little more pressure to pierce the skin with the orgalutran ones. watching my dh do it, its a little more awkward to administer, holding needle still while plunging - but again, you will get the hang of it after a few. you are already braver than me, preparing to do them yourself, so i reckon you will be fine!