I was doing the Colorado protocol with my last IVF cycle and they started both the predisone and clexane on the night before transfer.
One thing with the predisone is that if you have insulin resistance it is going to make it worse. With my diabetes my endo said to expect my insulin needs to double at least. We didnt make it to transfer so I only had taken the drugs the one night and my BSLs were okay not great but okay.
So yeah in short you probably do need to get your metfomin back to full strength first otherwise your pancreas may start complaining!!
Have you tried metformin XR? the extended release version - cos apparently that can be heaps better on the tummy.
Thanks Melbel for explaining things in ways that make sense! Something I seem to be chronically unable to do some days.
Diabex XR is a heap easier on the tummy - I'd imagine that it's easier to wean yourself on to it as well.
The assumption we are making this cycle is that my insulin resistance problem is way worse than my NK cell problem. Which evidence seems to agree with. 10mg seemed to be enough to keep the NK cells under control before we knew about them, and it was decreasing the metformin during my first pregnancy that caused the miscarriage. So we're opting for the middle line, and hoping like heck we were right the first cycle and it will work again this time!
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