Hi Constance,

I had my appointment with Gavin last week. We are going to progress with PGD (what was to be my first pgd cycle was cancelled due to poor response last time), as Gavin believes and I agree, we really need to tick that box off - ie its the only thing we haven't done. We are also going to do the cycle without prednisolone this time, just to see whether perhaps it has been doing more harm than good. I only have slightly raised uNK cells, so the clexane may be enough. But to answer your question, yes he treats NK cells with prednisolone and clexane. I didn't realise that Dr Sher had switched to prednisone, I thought he still used dexamethasone. But yes, I think the dex is stronger.

I then saw SIVF the next day and spoke to them about CGH. Whilst it seems like great technology, and I was very tempted to go ahead with them, I got cold feet . It is still in very early stages, and also they biopsy on blasts rather than day 3 embryos, and I know Dr Sher, who pioneered CGH, believes that day 3 biopsy is better. At the end of the day, I think I also really wanted to give Gavin a go with PGD. We still may consider CGH down the track if we think its needed.

And lastly I saw Dr Lamaro yesterday who is interested to see if my implantation failure may be endo related. I had a lap 2 years ago where some endo was removed but there was some around my bowel that they couldn't get to, which Dr Lamaro was concerned about. So I had a blood test, and am going to have a pelvic ultrasounds and sonohystogram at the beginning of my next cycle. He said to still go ahead with my pgd cycle as planned, and if we need to we can do a lap in December.

So I've booked in my pgd cycle, epu will be 2nd November. I am not holding out hope of a pregnancy, and it seems backward to say this, but I hope that all the embryos are abnormal, so that maybe maybe I'll finally get my answer.


Doctors ive spoken to are my doctor at Monash, had a quick chat to a couple of scientists doing work on implantation failure. Gab Kovaks at monash is working on a study for this and Im thinking of letting them take a biopsy of my endometrium next pick up, at least I can contribute something to the world of infertility. Their theory is very simply, protein imbalances in the endometrium/uterine. Did not go into detail with them. Although the scientist I spoke to said they were making some major revelations. Long time before we see the results. When I told her about nk cells she implied that it was all related.
Gavin spoke to me about something similar but I don't think the same, but through someone in the UK, at my appointment with him last week, and I also volunteered to help/contribute when the time comes.

Have you started your next cycle yet?

Gabbi