I have never used them rectally and didn't start using them until my pg was confirmed. I didn't use as many as you, one - twice a day and that was messy enough. I had cramping but I don't know if it was from the pessaries or the FSH and HCG injections. It might be best if you call your dr and talk to him about.

Good luck, I hope it is worth it and you get your BFP!