Klinefelter Syndrome anyone out there whose DH has this and doing IVF?

[blossom73]

Hi im a new member and was just wondering if there is anyone else out there whose DH may have Klinefelter Syndrome and had any success with IVF?

We are with SIVF and have just had cycle cancelled as not enough eggs, so along with the not knowing if my DH has any sperm we are now also dealing with the cancelled cycle and maybe low production of eggs, still very optimistic but very hard to stay positive all the time.

Thought id see if anyone else is going thru or has been thru IVF with Klinefelters.

________________________
Me 36 and DH 36
TTC - 2 years
IVF # 1 - Dec 08 cancelled
IVF # 2 - Aug 09 cancelled not enough eggs for collection

[redlady]

Hi sorry my Dh doesnt have Klinefelter Syndrome but he does have Familiar Adenosis Polyposis. It is a genetic condition inherited from his mother. It means the kids could get cancer and it gets worse with each successive generation. There is a 50/50 chance the kids could be affected. We thought about having PGD where they select the healthy embryos to reimplant but they dont have a way to test it in the case of Dh genetic disorder. So thats why we are doing donor sperm.

I hope someone helps you out with this. Has your FS discussed maybe doing PGD or using sperm donor.

Redlady

[blossom73]

Hi yes FS has spoken to us about donor sperm but we haven't gone into
much detail as we are still hoping that we find a couple of swimmers when they do a biopsy.
Fingers crossed that we can even get to that stage it has been a long and very frustrating ride!
Not too sure what PGD is!
N

[diva det]

hey natty
I have heard of couples with KS having success with IVF - If you want to email me or PM me- i can go into it further with you.
Good luck hun!!

[blossom73]

Thanks so much that would be great, not too sure about how to work this site.. How do i pm you or email you?

[blossom73]

hey natty
I have heard of couples with KS having success with IVF - If you want to email me or PM me- i can go into it further with you.
Good luck hun!!

Hi love thanks cant figure out how to work this site! How do i pm or email you.
Thanks would love to know more
N

[Chocaholic]

I think you need to have a certain number of posts before you can PM someone. I think it is 20 but could be wrong.

[redlady]

Hi

PGD is where they fertilise the eggs with sperm. then they test them to see which ones are healthy then they only implant the healthy embryos.

But as I have read you seem to have a problem with dh sperm being able to fertilise your eggs. ICSI might help. Its where they take sperm from your dh and they can even extract it medically, then they inject a single sperm into an egg. They incubate it and then put it back into the uterus to hopefully implant and grow.

Redlady

[redlady]

Hi Blossom73,


Im sorry I dont know more but I found a support group I hope this helps you out.

Klinefelters Syndrome Supprt Group

This is an Australia wide support network for men with Klinefelters Syndrome, their families and anyone with a professional interest.


PO Box 3

Glendinning Mail Centre 2761


Telephone: 0407 262 398


Email: yatesbecks@bigpond.comThis e-mail address is being protected from spambots. You need JavaScript enabled to view it


I really do hope this helps you.

Redlady

[Zoe->]

hey natty
I have heard of couples with KS having success with IVF - If you want to email me or PM me- i can go into it further with you.
Good luck hun!!

Hi,

I have tried to work out how to PM someone, but because I am new here, I don't think I have that option.. My DH is also very highly likely to have Klinefelter syndrome (everything fits, we are just awaiting the genetic testing..) .. I was wondering if you might be able to give me some info about the successes you've heard about with people with Klinefelter's and fathering children through assisted technologies?

I'm really hoping to hear from you soon,

Kindest regards,

Zoe.

[diva det]

hey zoe
yup you need to have a certain number of posts to be able to PM

Without going into too much personal details as it is a public form
in general
Not every cell in your body has the same DNA make up
men who are mosaic, (have a combo of both XXY and XY cells) have the chance of their arm may be affect by Klinefelters, but their legs may not- that is why it is a syndrome.
There is a chance with mosaic men that they could still produce sperm. Even if its a tiny bit

I know of a melbourne clinic who 10 years ago were having success extracting sperm through a biopsy of klinefelters men and successfully using ISIC to fertalise eggs and get a successful pregnancy.
even if sperm count is really low- they still may be able to get sperm through this technique. After all it only takes one sperm!!! LOL
good luck and let us know how you go!!!!!

[Zoe->]

hey zoe
yup you need to have a certain number of posts to be able to PM

Without going into too much personal details as it is a public form
in general
Not every cell in your body has the same DNA make up
men who are mosaic, (have a combo of both XXY and XY cells) have the chance of their arm may be affect by Klinefelters, but their legs may not- that is why it is a syndrome.
There is a chance with mosaic men that they could still produce sperm. Even if its a tiny bit

I know of a melbourne clinic who 10 years ago were having success extracting sperm through a biopsy of klinefelters men and successfully using ISIC to fertalise eggs and get a successful pregnancy.
even if sperm count is really low- they still may be able to get sperm through this technique. After all it only takes one sperm!!! LOL
good luck and let us know how you go!!!!!

Hi again,

Thanks so much for your reply, it's really nice to know there are people who are willing to listen and help you when you are having a really hard time...

It's a really lovely welcome to this forum

We are yet to find out if he is a mosaic Klinefelters, but considering his zero sperm count, very high FSH (42) and LH (19.9) and all of his 'physical attributes' fitting the stereotype, we are already pretty much convinced that he is probably non-mosaic..

I was wondering, did you know if any of the men from the Melbourne trial were non-mosaic? Did they have zero sperm counts or just very low counts?

There is some promising data I have found in a paper here:

http://humrep.oxfordjournals.org/con...3/588.full.pdf

But then again, these are all seemingly 'miracle' cases considering how many men are affected by this condition and how many are able to have successful biological children through reproductive technologies.. It's kinda weird, don't you think.. That so very little publicity is attached to Klinefelter's, especially when it is the most common genetic mutation found in the male population.. ?

[blossom73]

Hi Zoe I wish u luck unfortunately for us we where not one of the miracle couples and now using donor sperm still with no success yet! When I was researching and chatting to others about KFS there definitely where couples out there that manged to have children with dh having KFS!
Hang in there stay positive u honestly never know and miracles do happen x