WTH, it's not that unusual for E2 levels to start out slow and for puregon/gonal F to need to be increased. It happened to me on my first cycle and things went on to be mostly ok (sure, I had OHSS and couldn't transfer, but that's a PCOS thing and my first FET worked). I know of others that have had the same thing happen and have gone straight on after an increase to have a successful cycle and a successful pregnancy follow. They have a bit of leeway before things get too late in the cycle and they will cancel and try again from the beginning with a higher dose.

Don't give up hope yet!

BW