Thanks WLAB and WTH (so nice to hear from you!).

I had an appointment at the clinic this morning and they are not concerned about the lost droplet and gave me additional Pregnyl as well. I also had a "refresher" course at my request...here's what I learned (in case someone searches for this in the future):

- you must get all of the liquid in the liquid ampoule to the bottom of the ampoule (I had forgotten this part) - you do this by flicking or snapping your wrist while holding the ampoule - it may take a number of times to get all of the liquid out of the tiny top and into the bottom.

- to "snap" the glass off - firstly, you are not seeking to crush it (as I did), but it should snap off - and there's a little black dot which indicates where your thumb should be to get the best breaking point - she had me do it while holding a tiny alcohol pad that was still in it's wrapper as it gives you a nice cushion but not too much of one that you don't have any feel or control - so basically you put the wrapped alcohol pad between your thumb and the black dot and SNAP the top off. They let me try myself and it worked much better than what I did last night.

- ok, now for the part I still don't get - after you mix the liquid and powder by sucking up the liquid in the large syringe and squirting into the powder - to draw it in the small syringe for injection, you need to tilt the ampoule and suck it up in the small syringe. I don't really see how this works as by tilting it I felt like I was going to spill it and I think this method requires 2 people and DH wasn't around. I explained to her how I did it and they said fine. What I did was after it was mixed, I took apart the small syringe so that it is in 2 parts (plunger and needle/plastic tube) and I drew the liquid up in the large syringe and squirted it back in the small. Now for the hard part - I re-inserted the plunger part for the small syringe ever so slightly - enough to stay in place when held needle pointing up, but that's all - I then tapped, tapped, tapped like on TV to get all of the air up on the needle end and all of the liquid down closer to the plunger - this allows you to force all the air out before injecting.

Hope that helps future users!