In a recent Cochrane review a statistical analysis of pooled data from different trials that between day 2/3 transfer (cleavage stage embryos) and day 5/6 transfer (blastocyst stage embryos) there was no statistically significant difference between live birth rate per couple, pregnancy rate per couple, pregnancy rate per couple where fewer blastocyst than cleavage stage embryos were transferred, multiple pregnancy rate and multiple pregnancy rate where fewer blastocysts were transferred than cleavage embryos. The authors concluded that “The current evidence fails to support a widespread change of practice from cleavage stage to blastocyst stage embryo transfer in couples undergoing IVF.†Given the conflict of one centres trial results with this Cochrane review paper it may be useful to ask clinics their exact results of blastocyst transfer and specifically whether there is a true statistically significant difference between each technique.
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