Scarlett, I started on 150IU of puregon, and didn't respond. I was then increased to 300IU and ended up over responding with pretty bad OHSS and no transfer on our pick up cycle.

Having been there - starting low and increasing gradually is certainly safer when PCOS is involved. Trust that your FS knows what they are doing... but certainly scream like mad if they suggest such an enormous leap as was used with me.

I'm convinced that stimming longer and slower is much better than running the risk of hyperstimulating... been there, done that... pray that I never have to get anywhere near it again!

BW