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Thread: clexane during pregnancy

  1. #1
    mumof2beauties Guest

    Default clexane during pregnancy

    just after a little bit of advice from anyone who has been prescribed clexane during pregnancy...I am currently 9 weeks and 4 days pregnant after having 2 second trimester miscarriages (19 weeks & 23 weeks).
    Apart from being extremely paranoid and anxious that something is going to go wrong this time, my ob has suggested starting clexane at 12 weeks in an attempt to help the placenta attatch properly (which has appeared to be the problem in the past, although nothing has been confirmed).
    He has told me that clexane does not cross the placenta, so does not pose a threat to the baby, but I would love to hear from people who have been prescribed it, and what the outcome was.


  2. #2
    kirsty Guest

    Default

    Hi Hayley, it might be worth taking a look at these links:


    http://bellybelly.com.au/forums/view...hlight=clexane

    http://bellybelly.com.au/forums/view...hlight=clexane

    http://bellybelly.com.au/forums/view...hlight=clexane

    Hope that they can be of some help to you.

  3. #3

    Join Date
    Jan 2005
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    Narre Warren Sth
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    Hi Hayley
    After losing my son at 24.5 weeks they discovered that I had Antiphospholipid Syndrome (APS) or to make things easier, Sticky Blood! Since losing him I have had 2 m/c, one at 6 weeks and one at 11.
    I am now pregnant again and have this time started the clexane straight away. I have a 40mg shot everyday as well as half an asprin.
    If you have anymore questions feel free to ask.
    Sarah

  4. #4

    Join Date
    Nov 2005
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    QLD
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    Default

    Hi Hayley

    Yes clexane does cross the placenta but it dies not do any permanent harm to the baby

  5. #5

    Default

    Hi Hayley,

    Welcome to BB and congrats on your pregnancy!

    I am sorry to hear of the loss of your two little ones. I lost my first child, Georgia, at 2 days old. (After she was born at 35+5). She passed away due to complications caused by the same condition that Sarah1978 has referred to in her post above. (Like Sarah, it was detected after my loss).

    When I fell pregnant a second time, I took low dose Aspirin to treat the condition, however I miscarried at 9 weeks.

    When I fell pregnant for the third time, I again took low dose Aspirin but also did Clexane injections. I did the injections from 6w to 32w. My son ended up being born premmie at 32+4 (due to the same complications that had occurred with Georgia) but my specialist said it was probably the Clexane that got him that far. Apart from the usual premmie issues, he was totally fine and now at 4.5 months old, he is a healthy, happy little boy.

    Best of luck with your decision, Hayley and all the best for a happy, healthy pregnancy!

  6. #6

    Join Date
    Jun 2005
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    NEWCASTLE
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    Hi Hayley,
    i am sorry for your losses

    I too am taking clexane 40 inj daily but to help manage my arthritis whilst pg as i can't take my normal meds. I started taking it with 1/2 asprin daily from my IVF transfer and will be on it until about two weeks before being induced (36-37 weeks).

    I hope you continue to have a H&H pg.

  7. #7

    Join Date
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    Becc - did you have your son early because you came off the clexane or were you taken off it and induced due to your sons/your health issues??? I would be interested to know as my OB said i will come off it two weeks prior to induction, maybe i will ask her if coming off it will bring on labour.

  8. #8

    Default

    Hi kas,

    No, Josh wasn't born early because I stopped the Clexane. The plan all along had actually been for me to stop the injections at 32w as my specialist said that it would have done its job by that stage. As it turned out, it was just coincidence that he was born so soon after I stopped them.

    The reason he came early was because there were problems with the blood flow from the placenta and if he was left any longer, it would have become dangerous for him. I didn't go into labour...he was delivered by c-section as I couldn't be induced due to the fact that my first birth was a c-section also.

    I know a couple of other girls who took the injections and stopped them a couple of weeks before they were due and they were both fine. (No premature labour or anything like that).

    Definitely talk to your OB about it if you are concerned, but I'm sure you will be fine. Best of luck! O

  9. #9

    Join Date
    Jan 2006
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    Sydney
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    I gave birth to Caitlyn on the 15/11/05. She was stillborn at 25 weeks. My OB will start me on aspirin and clexane early into any future pregnancy to assist in placental implantation. Apparently the placenta implants initially and then further implants at around 22 weeks. I have notice since losing Caitlyn that many stillbirths occur at around the 25 week mark and it may be (just me guessing) due to placental insufficiency. I didn't know the placenta implanted further after the first trimester and her 18-20wk U/S was perfect. She was smaller than she should have been for dates when she was born so she may not have been getting enough to grow.
    Add to this the fact that I have Factor V Leiden ( a clotting disorder) and I become a high risk for at least the first 2 trimesters.
    Clexane has a very short half life (meaning it only lasts in the body for a short time) so my OB will not be ceasing my clexane. It will continue until labour / delivery. The aspirin will stop at around 30 weeks.

  10. #10

    Join Date
    Jun 2005
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    NEWCASTLE
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    Hayley - i hope all is going well for you.

    Becc - thanks for your reply. I didn't hink stopping the clexane would bring on labour, i just wanted to check.

    Michelle - I am so sorry for your loss of Caitlyn. I hope you and your family are doing better as time passes.

  11. #11
    mumof2beauties Guest

    Default

    thank you all so much for your replies...It is good to get other peoples experiences. I have my first appointment Wednesday with my OB, so I guess I'll know further then.
    Has anyone had any sort of placental dopplers to check on the blood flow through the placenta? That is an option I have too, which I think is like an ultrasound every couple of weeks.
    Here's hoping anyway....I think its gonna be a long 30 more weeks!!

  12. #12

    Join Date
    Jan 2006
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    I've been told that I will have an U/S at about 23 weeks to check on placental blood flow. The OB said the blood flow to the uterus is a different waveform to the blood flow waveform of the placenta. At 23wks they will be able to see what the waveform looks like and determine if the placenta has properly implanted. I will still have U/S every 2wks after that (regardless of the result) to monitor fetal growth. He says there are specific changes that occur that indicate fetal insufficiency and they will monitor for those changes throughout the pregnancy. I think part of it is reassurance for me (but that is great!!) but also because they know more and can intervene earlier to minimise the risk of fetal death (like this time).

    All I need to do now is get pregnant!!

  13. #13

    Default

    Hi again Hayley,

    I had umbilical artery doppler studies done during my pregnancy with Joshua. Like you said, it is just like a normal ultrasound, but with extra tests done to check on the blood flow. As it turned out, with me, the tests showed resistance in the blood flow beginning around 31w which only continued to get worse, leading to Josh being delivered at 32+4. So basically, having the dopplers done is what got him here safe and sound and I will have them done with any future pregnancies as well!

    How are you going? How did you go with your OB appointment yesterday?

  14. #14
    mumof2beauties Guest

    Default

    Hi Becc thanks for your reply again. my appt went really well yesterday, I have come out feeling a lot more confident. He wants me to start clexane 40mg next week up until about 36 weeks (hopefully we will get that far!!), which is what I thought, and he said he will get an ultrasound done 4 weekly till 22 weeks and then fortnightly. He also suggested some counselling to get through this period, which might be a good idea. He also said if I 'lose it' (my mind that is) I can call in to him anytime and he will do a quick scan to reassure!
    I have my fingers crossed anyway
    hope all is well with you
    hayley

  15. #15

    Default

    I'm glad to hear that you are feeling more confident after your appointment, Hayley.

    It sounds like you have a great OB! And it must feel good to have a plan.

    Good luck with the injections - they aren't so bad! Stay in touch and let us know how you are going.

    By the way, we are doing well here - thanks!

  16. #16
    bumpygirl Guest

    Default Clexane

    I, too, was put on clexane (40mg) and aspirin as well as progesterone right from the moment I thought I had conceived. This after 5 miscarriages between 6 and 11 weeks.
    The reason is a blood clotting gene mutation - blood that clots easily - I did the injections right up until birth (ideally you are not supposed to have injected within 12 hours of labour particularly because of epi and possible c-sec). As mentioned the clexane only lasts a short time in your system but I had to stop the aspirin at 36 weeks.
    Sophia was overdue and I had to be induced because of high blood pressure but nothing to do with the clexane or aspirin etc. She was a normal weight and is going well, there we never a threat of her being premature.
    Hope this helps
    Charlotte

  17. #17
    Mama Mo Guest

    Default Feeling a bit anxious...

    Hi there,

    I am SO happy I've found this site where there are other women who have experienced miscarriages and are now on clexane and low dose aspirin like I currently am.

    I already have 2 beautiful daughters Pania, 8yrs and Ana, 3yrs who make me want to have more childrens! After having 2 really healthy and easy pregnancies with both my girls I was astounded and devastated to lose 2 babies and be told there is no conclusive reason as to why I lost them...

    Both my miscarriages were during the second trimester, one at 15 weeks and the other at 17 weeks. After numerous tests and autopsies on both babies there wasn't really anything conclusive except for a positive ANA or anti-nucleic antibodies?? Apparently my body was producing antibodies that attacked the baby as if it is an infection in my body..

    ANYWAY, one of the specialists I have seen prescribed 40mg clexane injections along with half an aspirin tablet each day as he thought it has been possible tiny microclots were forming in the placenta blocking blood flow to baby.

    I feel good about being a lot more closely monitored, we had a scan at 12 weeks and it was magical watching our baby dance around and see the strong heartbeat. I also heard baby's heartbeat loud and strong at 13 weeks and so am continuing to hope and pray we get through this 'danger zone' and have a healthy baby in our arms in September.

    It's just great to find other women sharing their experiences. I think you are all really brave trying again and am LOVING hearing the ultimate happy endings where you have healthy babies in your arms.

    Thanks for sharing,
    Mama Mo

  18. #18
    Mrs Yusuf Guest

    Default CLEXANE or INNOHEP

    I conceived after 4 years of marriage,but it ended in missed abortion at 9weeks.then after 1 year,againgot pregnant but missed it at 5th week.I was then told that my Protein C is just at border line i.e just touching the lower base of normal rangeso i was given CLEXANE4000 for 3months daily.now after another 1 year,I have just got pregnant.cant find clexane and have been given INNOHEP instead..does anyone has experience about it?i see that CLEXANE medical name is Enoxoaparin sodium and INNOHEP medical name is Tinzaparin sodium.Please tell me about its safety and if anyone has personal experience on it.Also i guess most start tehse ijectables form second trimester.Why am i been told to take straight away.

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