MD - I know you don't want to hear it, but have you tried cutting out sugar? Apparently it upsets quite a few babies. Will was so unsettled and grumpy with reflux but the past week since I stopped treating myself to lots of yum things he has been so much happier. I had a sugar free day last tuesday, he slept a bit better that night and by wednesday was feeling much better so it would only take a couple of days to find out if that is a cause. I am sure you have already ruled out diet causes, just a thought since it solved our problems (well, solved his - I am left with nothing yummy to eat).