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thread: IVF with PGD #6

  1. #19
    Registered User

    Sep 2009
    central QLD
    1,834

    Not after but it was always late waiting to start a cycle, i think its a mind thing. I was waiting for it so it didnt come. If you dont want it to come it does!
    x

  2. #20
    Registered User
    Add kimmi on Facebook

    Oct 2009
    Brisbane
    736

    Yeah, I agree with Jaki, it's amazing how your mind processes can change your body's functions. Grrr, so frustrating for you.

    We are starting injections for our second cycle tomorrow, so really looking forward to it. Fingers crossed again and Jaki, send some of your good luck our way

  3. #21
    Registered User

    Feb 2010
    Melbourne
    39

    Figures...this morning I got my period!

    Jaki80- You must've been right! Hope you're feeling well in your first trimester!

    Kimmi - Best of luck this cycle! Keep us updated. Jaki80 and Mylitta need to blow some babydust our way - most definitely!! haha.

    Foxy77- Best of luck to you too! I have thought so much of doing the second cycle and then if it doesn't work...would I do a third? YES. But, I would personally be waiting maybe 6 months or so. Just to give my body and mind time to recover....plus, I'd need "normal" time (without dr's appt's and meds).

    I gave my nurse and doctor a call this morning to get on the schedule for Oct injections. God willing we will all have some good news by years end! What a wonderful thing that would be!

  4. #22
    Registered User

    May 2010
    Australia
    38

    Kimmi - how are you going?

    Mia's mama - that's exciting you're starting again in October - not so far away now!

    I started injections today, it's exciting after waiting so long! US this Friday, hopefully the stims will work better this month. I'm on 600 units gonal F plus 75 units levaris - they're pulling out all stops this time so hopefully it will be our month!

  5. #23
    Registered User

    Feb 2010
    Melbourne
    39

    Foxy77 - So good to hear the doctors are going "all out" this cycle!!! I sincerely hope this is your month!

    Kimmi - How's your injections going?

  6. #24
    Registered User

    Sep 2009
    central QLD
    1,834

    Good luck foxy!!!!!

  7. #25
    Registered User
    Add kimmi on Facebook

    Oct 2009
    Brisbane
    736

    Hey Ladies,

    I haven't been around for a few days.. But injections are going well! I had a scan this morning and it appears (although they are still small) I have about 11 follies coming along nicely. That was a huge relief, I was convinced that nothing was happening and this cycle would be canceled too!

    I'll do another week of stims and at this stage, subject to a scan on Friday I will be having epu on Monday or Wednesday of next week.

    Foxy - Fingers crossed for you... I'm only a couple of days ahead of you in stims, so best of luck to us both I say!!

    Mia's Mumma - October is JUST around the corner, it will be here in no time!

  8. #26
    Registered User

    Aug 2010
    57

    Hi Ladies,

    I am about to start a PGD&IVF cycle because of DH's balanced translocation. I was told by genetic counsellor that the normal embryos and BT carrier can now be differentiated but during the nursing interview scientist told me it is still in the testing stage, and it is not likely to differentiate them. It seems some ladies here have their embryos tested as normal or carrier. I am a bit confused...I am with SIVF.

  9. #27
    Registered User

    Oct 2007
    Caroline Springs
    2,341

    Hi Molisa and welcome!

    My first IVF cycle with PGD resulted in all of our embryos having chromosomal abnormalities. Because this was a pretty high rate of abnormalities, DH and I had a blood test that looked for chromosomal abnormalities in our own genetics. We were told it was possible (but still unlikely) that one or both of us may have a balanced translocation, so while we were waiting on our results I looked into it a bit and asked some questions about what it meant in regards to future embryos and PGD testing.

    It turned out that both of us were given the all-clear, but it was good learning about it anyway. From what I was told, PGD testing can be done to look for the specific balanced translocation that your DH has. With normal PGD testing they use a technique of analysis called FISH which cannot differentiate between the presence of a balanced translocation chromosome and a normal chromosome. So when one person has a known balanced translocation they create a test specific to the translocation they are looking for. Then they can tell you which embryos are clear of the translocation, which have the balanced translocation, and which ones have an unbalanced translocation. I'm guessing it would then be up to you as to whether you would want to only transfer "normal" embryos, or if you would also want to transfer the embryos with the same balanced translocation as your DH (as the child would be normal like your DH, they would just be able to also pass on that translocation to their children also).

    I hope that has helped you somewhat. Good luck with your cycle!!!

  10. #28
    Registered User

    Sep 2009
    central QLD
    1,834

    Hi Molisa........ I am also with SIVF, i have my embies tested for carrier and for affected. However im not sure if it is because the disease i carry is sex linked... so if its an affected boy it has my disease and is its an affected girl it is a carrier. Im not sure if this is what they do but i presume it must help in my case that is is sex linked, other wise they wouldn't even look at the sex.
    Good luck and keep us posted!

    Kimmi and foxy i hope your injections are going well and your EPU's are just around the corner!

    xoxo

  11. #29
    Registered User

    Aug 2010
    57

    Hi, Mylitta and Jaki,

    I just got my FE's reply back as below:

    The scientists may in the future be able to differentiate between carrier and normal embryos but at the present time this is not possible.

    Very disappointed...

    Not sure if I should go ahead with it, don't want my children to be a carrier.

    Jaki, congratulations on your pregnancy, amazed by your third time try!

  12. #30
    Registered User

    Sep 2009
    central QLD
    1,834

    Thank you, we said we'd give it 3 go's and thats what it took.
    As for the carrier thing, i'd rather have carriers than children who would suffer from a disease. Imagine what technology will be like when our children are having children.
    x

  13. #31
    Registered User

    Sep 2009
    central QLD
    1,834

    goodness, i just googled your DH's gene and i didnt understand anything it said!

  14. #32
    Registered User

    Aug 2010
    57

    Basically just a part of his two chromosomes switched positions. He is the only one who has the problem in his family which I guess could be attributed to his mum's age (40) when gave birth to him. I just started my work up process which will take a while (8-12 weeks it is said). I am thinking maybe I try naturally once while I am waiting. Do not know if it is a wise idea.

  15. #33
    Registered User

    Sep 2009
    central QLD
    1,834

    Have you seen the genetic dude at Sydney genetics? He was awesome. He is in the same building as sivf. He may help rationalise things for you. It's so hard to make these desisions! If you want his details I can pm them to you.

  16. #34
    Registered User

    Oct 2007
    Caroline Springs
    2,341

    Molisa, I definitely won't tell you TO try naturally, or to NOT try naturally, but I wanted to mention that unbalanced chromosome translocations very rarely result in pregnancy, and if they do they most definitely end in a miscarriage. It's because when it's unbalanced there is actually genetic information missing that is essential for life. For that reason if I were in your position I would probably try anyway, unless you were only planning on transferring embryos that are not even carriers of the balanced translocation (which it sounds like they can't distinguish for you yet).

    As for your concern about whether to even go ahead with it considering the limitations of the test, well I'm assuming the main reason that IVF with PGD is used in a situation like yours would be to reduce the number of potential miscarriages (or months where you don't even seem to conceive) because you are more likely to create embryos that have chromosomal abnormalities.

  17. #35
    Registered User

    Feb 2010
    Melbourne
    39

    Molissa - I completely agree with everything that Mylitta has to say!!!

    I had my daughter naturally and quickly. However, when trying for number two, I had several miscarriages - like 6. We were tested and I have a Paracentric Inversion in chromosome 22.......MIVF made a test just for me and my chromosome. They also do the "generic PGD test".

    Best of luck to you and whatever decision you make.

  18. #36
    Registered User

    Aug 2010
    57

    yeah, I had two miscarriages in the past 6 months, none of them passed 6 weeks. Since my second miscarriage, I have seen 2 GPs, 1 OB, 2 Genetic Counsellors and 3 FS. Apart from these two M/C, my first pregnancy, I didn't know I was pregnant then and did three vaccinations which could have big damages to the embryo , had to be terminated as suggested by Dr. That one was going well before we stopped it. Theoretically we should have 50% chance to have a healthy pregnancy according to GC, and there is also a small chance that a baby with unbalanced chromosome be carried to full term with serious mental and health problems. I understand the risk of M/C and just like to push my luck a bit. Life has been very tough for me in the past year, I lost my beloved father and then 2 M/Cs, I think I am strong enough to handle another M/C if it is meant to happen...

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