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Thread: IVF with PGD #6

  1. #199

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    Congratulations, Jaki!!!


  2. #200

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    EJE - I don't know her details.

  3. #201

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    Thanks anyway. Just looking for some inspiration at the moment as our journey for another Ivf miracle seems to be slipping away.

  4. #202

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    EJE - no, for me it was for recurrent miscarriage/failed IVF after multiple embryo transfers. We did 2 fresh PGD cycles, 2 regular fresh IVF cycles and 5 FETs. I am incredibly impressed that you have survived 9 fresh PGD cycles. How are you going? What are your specialists recommending? How are you feeling about it all? Have you been getting "normal" embryos? Have you been tested for immune issues including NK cells/have you had any pregnancies since starting the PGD and been tested for recurrent miscarriage (I guess this is how your translocation was found)? Where are you doing PGD? Hope not too many questions. I am in awe of you.

    Jaki - congratulations!!! Great news!!


    Molisa - how are you going?

  5. #203

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    EJE--That is the question I was devastated to know after we failed the first cycle. Below is the answer from my PGD scientist. Hope it is helpful to you.


    It seems daunting because the % unbalanced is quite high at 70-75%. However, the use of a stimulated cycle means that there are enough embryos created to give a good chance of having one for transfer. Our success rates can only be determined with cycles that have a transfer and we see implantation rates of 50% for women <38 yrs. The average number of embryos biopsied is 3.4 but 15% get no biopsy at all. 86% of couples with a biopsy have a transfer and 50% of those have a foetal heart pregnancy at week 8. This translates to 30% of couples have a foetal heart pregnancy on their first transfer of their first cycle. So you can see that unfortunately it is a matter of statistical chance that you have a suitable embryo to transfer and once this is identified the chance of a pregnancy is quite good. The IVF-PGD process is one where the number of chances you have access to are increased. It can be daunting when things don't go the way you want but nothing is guaranteed in the process for any couple entering. When you look at it objectively though, PGD gives the highest chance of success in the shortest time.


    Foxy, I didn't know that you have the translocation problem. You are lucky to have three normal ones to transfer after two IVF+PGD cycles. Hope we can have better luck this time. I just had my first BT yesterday. My E2 was not as high as the first one under this long cycle. It went up to 1300 same time last cycle and reached 8000 when triggering.

  6. #204

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    Good luck Molisa. Keep us posted

  7. #205

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    We found out that DH had a balanced translocation (18 & 21) after many miscarriages. We were tested for everything but not sure if that included NK cells- what is this? And the karytope test revealed the translocation. We then found out about PGD Ivf and once our probe was built did our first cycle. That cycle collected 12 eggs, and 4 were suitable for testing and of those one was fine. That one is now our precious 3 year old boy . Since he was one we have no attempted 8 more for a sibling. I am what you call a good chicken and produce lots of eggs on low doses of fsh. The lowest number has been 15 eggs, and the last 2 cycles we have had 21 and 22. We have good fertilization rates, using Icsi ( even thought we don't need to use Icsi, we do just to make sure we have good fertilisation iykwim) . Last cycle was had 15 fertilise and 10 to biopsy/test. All 10 had the translocation. Cycle before we had 8 to test and again all carried the translocation. We had another cycle where although we only had 5 to test 2 amazingly were fine. We put both back in / transferred both but for some reason they didn't make it.

    We are with MIVF.

    Do you have any suggestions for what we could do differently? I have done some cycles with accupuncture, but this doesn't seem to have made a difference.

    On a side note, I have underactive thyroid and pcos, and seem to get ohss everytime, including when I was pg with ds. Ohss is REALLY horrid.

  8. #206

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    Oh and Molisa thanks for those stats. We have basically been told that on paper for us that I in every 10 biopsied/ tested we should get one that is fine. Butbeven though we have had cycles with 10 to test thus doesnt seem to be the way it works in the real worl iykwim. Seems to be more a case of genetic tatslotto. Can I ask who your scientist is with?

  9. #207

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    You are very very fertile. What you do or not do don't alter the likelihood of a balanced chromosome set occurring. That 1 in 10 likelihood is estimated by your scientist specifically for your DH's involved chromosomes and breakpoints? What I was told by my lab is they observed 1 in 4 is genetically balanced from their own data. It can 'vary according to the amount of chromosome involved and which chromosomes are involved but seems to vary from run to run'. I also searched some technical literature and the reported sperm normal rate for male BT varies from 20%-50% based on the FISH analysis. But my scientist also commented that 'testing of sperm is error prone and does not necessarily give accurate detail on the true % normality'.
    I joined a BT Yahoo group and there are many BT couples from all over the world. I don't check it very often. But last time I checked I saw a couple hit the genetic lottery and they naturally conceived a completely normal baby (not even a BT carrier). Another couple from the USA got 3 fine ones out of 14 tested.

    I am with SIVF.

  10. #208

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    Our scientist has also told us the likilihood if 1 in 4 being affected too, but they said this statistic was outside of Ivf, and what they found was that for Ivf it ends up being a 1 in 10. I think though this is for 18 21 cases. I can't believe that someone got 3 from 14. Do you know if these transferred successfully?


    We have not had any sperm analysis done for our translocation before. All our testing has been done based on the karyotyping. Have you had sperm analysis done specifically to analyze your translocation?

  11. #209

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    I don't know, I didn't follow up.

    We have no plan to do such test.

  12. #210

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    WOW EJE, you do have good numbers... Keep focused. I'm thinking of you all

  13. #211

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    EJE - sounds like it's a numbers game for you, like you say. 2/5 sounds great, must have been a major blow your last few cycles that you haven't had any normal embryos. I don't know much about balanced translocations (my PGD was for failed IVF/recurrent miscarriage) - do you know if they test your embryos for all the chromosomes or just specifically for the BT? If they don't test all the chromosomes, a small chromosomal problem (random) might have been the reason these 2 embryos didn't take? Your egg numbers sound amazing, which is great, especially as you only need a small dose of FSH - but OHSS each time would be horrible. I was on 600 units to get about 8-10 eggs, my ovaries aren't very good, even though I'm only 33 - my FSH was high.
    I can see why you've kept going and I would encourage you to keep doing so (if you can!) from what you've said - sounds like it's a lottery and if you keep going, you will most likely get there eventually. How are you coping with all the cycles?

  14. #212

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    Yes they do test other chromosomes too, which is why it was so upsetting that our 2 didn't make it. They told us that sometimes it happens without any real reason, and once that they do a transfer, then we are in the category of all pregnancies ( ie including people without transoocations) and one in three will fail.

    The highest fsh I have been on is 225. I can't imagine what would happen if they put me in 600!!!
    I am determined to keep going, but our major problem is coming up with the money. We will have enough saved for one more cycle later this year, but after that will have run out. I don't want to go and buy a tatslotto ticket to help us out as I would prefer to save any luck coming my way fir a bfp!

    Emotionally the cycles make me a wreck ( as well as the major physical toll the ohss takes) but I am determined to put that aside rather than to give up.

  15. #213

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    Nervously waiting for tomorrow's PGD results...

  16. #214

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    I have everything crossed Molisa... x

  17. #215

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    EJE, don't lose hope. Sometimes bad luck just happens and you just have to hope for the best next time. I went through two PGD cycles and from 31 eggs we got one precious little chromosomally healthy embie. We don't have any underlying chromosome problems, so you can imagine how devastated we were when all our tested embies from our first cycle, and all but one embie from our second cycle had chromosome problems. We had a much higher rate of problems that the average, yet sometimes it happens

    I wish you all the best and hope you have some good luck soon!

  18. #216

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    Hi all,

    We had two completely normal ones and transferred one this afternoon. Can't believe we can even have a spare one. Not sure if it is because of the herb DH was taking.

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