PGD has many forms, none of which really look for DNA fragmentation in an embryo unless a known DNA deletion or translocation is known in the parent. The most common form of PGD looks at only 6 chromosome pairs only includig x and y and isnt actually testing at the genetic level it is merely doing a head count of these six chromsome pairs to make sure there are two of each. Basically they are stained with a radioactiive dye and what shows up under the microscope will be 2 red blobs 2 green blobs etc. If there is only one red blob or there are three purple blobs etc, you have a dodgy embryo and it is discarded. If you wanted to check for a genetic disorder which is the level that DNA fragmantation occurs at you would have to know exactly what gene strands you are looking for then the scientific team spend months finding a contrast that shows up that strand or gene (lke say the cystic fibrosis gene), then and only then can they use that contrast to test one of your embryos for that particular defect. It is a very specific test and will not pick up any other anomolies in the embryo.
Short answer PGD cannot check for DNA fragmentation as such unless the fragmentation is exactly the same in every single sperm which would indicate the father had a chromsomal translocation issue himself.
DNA fragmentation testing of sperm can identify a problem but is of no use in the IVF process beacuse the spermatozoa is killed in the process.
Quick lesson in PGD 101....hope that helps.




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