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Thread: metformin

  1. #1

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    Default metformin

    hi all, i hope some of you can help !!!!! i have just been prescribed metformin to control pcos after ivf cycle and mc @ 6 weeks in oct 04 can any one tell me whether there are side affects and how it affected you i am also having accupucture to help get my cycle back to some sort of normal pattern ( heres hoping ) 8-[


  2. #2
    Pietta Guest

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    Hello,
    I currently take metformin and did until i was 11 weeks preg with DS.
    The side effects I had were getting pregnant!! because the metformin helped me actually ovulate because i hadnt in 6 months, we tried and wah-la pregnant!!
    Besides that I have less facial hair and a much less painful period. It really helps your sugar levels as well, but of course we dont often notice that.

    I hope this helps. I recommend Met to anyone who has PCOS and asks!!

    Good Luck!!

  3. #3

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    hi thanks for your reply, i have done a bit of research since i posted today and some of the side affects i found are getting the trots quite bad and dizzy spells and also nuasea did you have any of these problems. i won't be ttc for quite awhile yet as my DH has to have a vasectomy reversal before we can do any thing more, we did do an ivf cycle in sept 04 but i didn't agree with any of the drugs and became violently ill only to MC early Oct 04 so at the moment we are trying to fix me so that i am ovulate and hopefully my cycles will try to be normal for the first time [-o< thanks for listening

  4. #4
    Sal Guest

    Default

    Hi there,

    I have just been posting in the Long Term TTC and IVF forums, as I am on that merry-go-round at the moment.

    I'd love to hear about people's experience with Metformin, in particular whether it was you or your doc's idea to go on it, plus whether only overweight women are seen as 'good' candidates. When I saw my IVF doc I asked about Met, and he said that he'd be willing to put me on it but didn't really think it would do me any good, seeing as I wasn't overweight and didn't have excess facial hair or acne (obviously my make-up works wonders :-$ ). Anyhow, I decided to start an IVF cycle rather than do Met/Clomid (I have already had the 'pleasure' of being on Clomid...am dreading menopause after having that experience...).

    I am wondering if there are any docs out there who take the PCOS/diabetes link seriously. I notice on US web forums that that is a big concern, but it doesn't seem to be on the radar here.

    For those on Met, can I ask you whether you did the glucose challenge test first and whether you were found to have insulin resistance?

    Any information would be greatly appreciated... My IVF cycle wasn't successful and I can't afford to be on the IVF rollercoaster so am now wondering whether Met might be something that could work for me.

    Thanks!

  5. #5

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    Hi babydreams,

    I've been taking Metformin for a few years now and I have found the side effects to be diarrhoea, nausea and occasionally vomiting BUT I have found that if you take it with a meal (generally halfway through eating) it is not as uncomfortable on your body. A lot of people have told me that this may only last for the first 2-6 weeks, but I go through patches of it occasionally.

    It also depends on the dosage your doctor prescribed. They generally ease you onto it step-by-step so it isn't as harsh. I now take 3 tablets a day, spread out through the day. At first I was taking them all together and I was a mess, and mentioned this to my specialist only a few months ago and he explained that I shouldn't be doing it like that - so that's something I learnt the hard way.

    The other thing I learnt the hard way is that if you have PCOS and your gyno prescribes it, talk to them about it and understand why. My ex-gyno prescribed it for me about 4 years ago and I never knew why. My chemist said to me - Oh, I've never seen a gyno prescribe this before, then when I went to my GP about the side-effects I was experiencing, he told me to stop taking it because my gyno must have prescribed me the wrong thing. Remember this was a few years ago, when it wasn't as common as now. Anyway, the moral of the story is, I stopped taking it, thought my gyno was crazy and then discovered I now have Diabetes Type 2, and if I had of taken the Metformin for the last 4 years it would have helped avoid Diabetes. This was never explained to me, and I had no idea why I was taking Metformin.

    Sorry for the long story. But that's my experience with Metformin


    Cheers
    Belinda

  6. #6

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    Hi sleebly - Just a few quick words in response to your questions.

    I didn't have any excess facial hair or acne problems, however my weight has been up and down for years, and such a struggle, so I assume that plus the PCOS is why they initially recommended it.

    I have been to 3 different gyno's over the last 5 years and they have all recommended this path to me, and told me that IVF is my last option.

    I was due to start Clomid in July 2004 but I opted for some extra blood tests that my gyno said were not compulsory, and then discovered I had Diabetes type 2, and so now she doesn't want to start me on any other treatment until my Diabetes has been under control for 6-12months.

    Cheers
    Belinda

  7. #7

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    hi and thanks for your replies before i was prescribed met i had a series of blood work done U/S 's and consults after suffering quite a large cyst rupture, i am not over weight according to healthy weight range and i don't have a problem with excess hair but do suffer acne but my bloods did show high colesterol and high Bsl"s and he also said that my hormone levels were within range so thanks again for your replies

  8. #8

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    For me the side effects are pretty similar to others. My Dr advised me to take the dosage slowly ie 1 tab for 1 week before bed then up to 2 then so forth as it helps your body to adjust easily. I have found this works better than starting from scratch with a full dosage as that does tend to put your poor body in a spin! For me eating is really important, if I miss a meal I get nauseous, and sometimes even diarrhoea.

    But to be completely honest, its all worth it IMO, my weight has dropped since on met and I have lots more energy too!

    Just remember a few things, don't take any medication that may contain asprin. And Alcohol is a big no no, although I did check with my Dr and he advised me that if I am going to have a few drinks then the best solution is to miss the tablets of that day and start again the day after. But its always best to check with your Dr first

    *hugs*
    Cailin

  9. #9

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    thanks cailin,
    the information on the alcohol came in very handy i have four xmas parties over these next 2 weeks so i will modifiy for these occassions, when i went back to my gp for a follow up i had gained 2 kg i was stunned to say the least but he increased my dose and in the last 2 weeks i have noticed that my clothes feel a better fit and i have continued to chart my cycles and so far this cycle is clock work i O'ed on day 14 so will soon find out if if being on metformin has finally given me a normal 28 day cycle
    so thanks for reply
    and have a merry christmas

  10. #10
    Pietta Guest

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    Hey Cailin,
    Why cant you have alcohol with metformin? What happens?
    My doctor takes the diabetes/pcos link very seriously. My doc is fantastic and he prescribed met for me. After taking it for 4 weeks i had lost weight and fallen pregnant naturally. I never experienced those side effects recently but i have only been back on met for a while.

    If you were in Perth i could prescribed my doctor to you!

  11. #11

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    Alcohol consumption along with the use of metformin can cause Lactic Acidosis which is a build up of lactate in the blood stream. Our liver converts the lactate into glucose and releases it back into our bloodstream, but when our body produces too much lactate our liver can't cope so it ends up staying in our blood stream which can cause complications. Worst case scenario is that it starts to have a negative effect on our organs and even organ failure. I have done a bit of research online, and have found conflicting evidence. Some studies say there is no proof yet others outline an increased risk with the use of metformin, especially with excessive alcohol consumption. It does say in the packaging (well the one's I have had) that it is recommended not go over 1 standard alcoholic beverage per day. But I do know of people who have gone ahead and drank as they normally would with no effects. I personally don't want to take that risk, so if I know a social event is coming up I generally skip that days meds and start again the following day. Better to be safe than sorry. And as my Dr has said, there is no point in not living And skipping a day here and there (so long as its not on a regular basis) shouldn't really affect the metformin. However I have noticed that when I do skip a day I do tend to get quite sluggish the next day or even a few days later (but that could be just me). But my best advice would be talk to your Dr about it as I am sure he/she can outline it more

    *hugs*
    Cailin

  12. #12
    Nat Guest

    Default Perth Doctor

    Hi Pee,

    I am in Perth and would love the contact details of a doctor who believes in the benefits of Metformin. My doctor disgnosed me with POS but didn't believe I would benefit from Metformin and I would like a second opinion, as I have not had an ovulation with clomid alone.

    Cheers
    Nat

  13. #13
    redmoon Guest

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    hi, gals!

    chandra here and i also have pcos. i took clomid for it early this year and got pg for 2 months then miscarried.

    i have regular cycles but the flow is irregular. don't have much facial hair or other physical symptoms but am a bit overweight.

    i've been reading up on pcos through google search and found some very interesting articles. it says pcos isn't a sickness per se but a consequence of our body to be insulin resistant causing havoc to our hormones. this is very new for me eventhough i've been researching about pcos since i was diagnosed last year. so the various linked articles recommends to start first with a natural remedy of exercise and low-carb diet to lower the insulin resistance of the body. as long as one can keep this up, the body will consequently react by decreasing the male hormones and improving fertility.

    i'm not sure but i'm willing to try this since it's quite safe and no side effects. clomid was horrendous to me on my last cycle. i was tired, moody, irritable, etc....! i had to take a break from it this last 2 months cuz i don't think my body can handle it anymore.

    hope this helps.

    take care

  14. #14
    redmoon Guest

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    oh, also metformin is actually a drug that controls insulin also!! so you might want to check this out with your doc

  15. #15
    Pietta Guest

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    Hi Nat,
    I responded to you in another forum but my doc- Dr lauw at Joondalup drive medical centre is brilliant!!

  16. #16
    kewpy Guest

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    I hope that you don't mind me asking but what is the major differences between this Metformin drug and Clomid drug? or is it a bit like Endo, there are a few drugs that you can take.

    Just interested as I have endo but like to learn and keep up to date with PCOS seeing how some people with endo can get PCOS as well.

  17. #17

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    Hi everyone,
    This is my first post here, I only really found out I had pcos this week. My last gyno mentioned something about it but didn't really tell me about it. I tell you what, it is interesting to read your posts as I have always had really irregular periods-would have none for 6 months and then one which was really heavy for three months etc. I was put on clomid which straightened out my cycles to around 35 days but didn't fall pregnant (since found hubby to have low sperm count and abnormal sperm), was on clomid for 18 months!!
    I also have always had facial hair and since starting clomid have it on my belly and darker hair on my arms, I hate it - I feel like a man!!
    Also suffered from bouts of anger and depression for which I've been on effexor and epilim (now off epilum) for about 8 yrs. I really wonder if it's all related to pcos. Also get thrush alot - is this to do with pcos.
    Sorry - I sound like a hypochondriac but have always been all over the place with mood, period, weight (though I'm not over weight, just fluctuat) thrush, hair and am now wondering if it is all to do with pcos - what do you all think?

    Really sorry for the big blab - but it is just so relieving to hear that others are experiencing similar things!!

    Luv Carrie

  18. #18
    Sal Guest

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    Hey Carrie, a lot of what you wrote is spot on for me, too! No way that you are being a hypochondriac, I am similar in that I keep reading about other symptoms that fellow PCOS women can get and they match my experience.

    IKWYM with mood swings and depression. I've been on Zoloft, Effexor and Lexapro for depression. It's always felt like something deep within me, rather than something that can be fixed with pills, IYKWIM.

    I am currently on Metformin and amazingly this has had an impact on my mood swings - I am getting much less of the extreme irritability. I am hoping it will also help me fall pg.

    As you have been dx with PCOS, it may be worth asking your specialist about it.

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