BW crinone gel comes in a single use tube...there are 15 in the box.....it is simply a controlled release form of progesterone and the standard is one tube each night before nye nyes!! Witht the other icky pessaries they have a wax coating which accumulates up there and tends to come out in a big blob every now and then or so I have heard. I am finding the crinone quite easy apart from the misleading crampinees and sore BBs